Vitamin K2 could be novel therapeutic target for common cardiovascular condition

ba04826b-fcc6-419b-b99f-6604a2724b70articleimage.jpg

23 Nov 2017 --- The European Heart Journal has published a review paper that highlights the potential of vitamin K2 supplementation for calcific aortic valve stenosis (CAVS), a common cardiovascular condition in the aging population where no medical therapy currently exists.

According to researchers, once symptomatic severe CAVS has developed, there is a dismal prognosis without intervention. Currently, the only treatment for (symptomatic) severe CAVS is surgical or trans catheter aortic valve replacement (AVR), but it is an intervention to which not all patients are suited.

While multiple trials have attempted to repurpose commonly used pharmacological interventions to slow CAVS progression, pharmacological interventions have thus far failed to alter the course of CAVS. The review paper notes that studies have demonstrated that statins, widely used for lipid lowering in atherosclerosis and inflammation, have no effect on CAVS progression or clinical outcomes, and might actually exacerbate the condition.

However, the researchers noted promise with vitamin K2, specifically the long-chain menaquinones (MK7), as they are transported efficiently beyond the liver. “Vitamin K supplementation is an attractive option to replenish vascular vitamin K stores to ensure optimal calcification inhibition,” the researchers write.

“Recognizing that medical therapies are proving ineffective, researchers are shining a light on efficacious supplemental alternatives, which leads them to the clinical research that NattoPharma has spearheaded,” says Dr. Hogne Vik, Chief Medical Officer with Norwegian-based NattoPharma ASA, a company targeting vitamin K2 research and development. 

“Specifically, our three-year cardiovascular study in healthy postmenopausal women taking just 180 mcg daily of Vitamin K2 as MK-7 (as MenaQ7) demonstrated a cessation and even regression in arterial stiffness,” Dr. Vik adds. “The relevance of our three-year study has resulted in several studies by the medical community for patients with existing coronary artery calcification, aortic valve calcification, and peripheral artery calcification.”

The review paper concludes: “The pathophysiological mechanisms involved in CAVS initiation and progression are being rapidly elucidated and include inflammation, fibrosis, and calcification. With this advancing knowledge, we have identified novel therapeutic targets like vitamin K and new imaging techniques that can be used to test the efficacy of novel agents and further inform our pathophysiological understanding.”

In an interview with NutritionInsight earlier this year, Eric Anderson, Senior Vice President of Global Marketing and Business Development at NattoPharma, underlined the company’s commitment to supporting research into the benefits of vitamin K. “When we look at vitamin K2 as menaquinone-7, we believe this is everything that is good about the natural products industry,” Anderson said. “Researchers discovered K2, and NattoPharma supported its substantiation.”

“We’re only supplying the active, menaquinone/vitamin K2; these studies are being paid for by traditional medical doctors who are treating diseased patients, and the only active is a vitamin,” Anderson said. “That’s what it really should be about: You have science, science leads to discovery, which in turn leads to an investment into proving that [an active] works as a dietary supplement.”

References:
Peeters FECM, et al. Calcific aortic valve stenosis: hard disease in the heart. Euro Heart J (2017) 0,1-8.
Knapen MHJ, et al. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: double-blind randomised clinical trial. Thrombosis and Haemostasis (2015) 19;113(5).

Related Articles

Nutrition & Health News

Soy, cruciferous vegetables linked to fewer breast cancer treatment side effects

11 Dec 2017 --- Consuming soy foods and cruciferous vegetables – such as cabbages, kale, collard greens, bok choy, Brussels sprouts and broccoli – may be associated with a reduction in common side effects of breast cancer treatment in breast cancer survivors, according to a team of scientists led by Georgetown Lombardi Comprehensive Cancer Center. Understanding the role of life style factors with regard to the side effects is important because diet can serve as a modifiable target for possibly reducing symptoms among breast cancer survivors.

Business News

Consuming sugary drinks during pregnancy may increase asthma risk in mid-childhood

08 Dec 2017 --- Children between the ages of 7 and 9 may be at greater risk for developing asthma if they consumed high amounts of fructose in early childhood or their mothers drank a lot of sugar-sweetened beverages while pregnant, according to new research published online in the Annals of the American Thoracic Society.

Business News

Kappa Bioscience reveals free vitamin K2 MK-7 quality testing program

06 Dec 2017 --- Kappa Bioscience has announced the worldwide launch of a free vitamin K2 MK-7 quality testing program. The program, announced at CPhI India, is open to finished K2 products, from any source, for testing and verification of the product’s K2 label claim. The program supports wider goals of educating markets about K2 stability and advancing K2 science to resolve the question of why unprotected K2 is unstable in mineral formulations. 

Business News

Exercise changes gut microbiota independent of diet, researchers report

05 Dec 2017 --- Exercise alone can change the composition of microbes in the gut, according to two studies – one in mice and the other in human subjects. The studies, which offer the first definitive evidence of the hypothesis, were designed to isolate exercise-induced changes from other factors – such as diet or antibiotic use – that might alter the intestinal microbiota.

Business News

Novel seaweed extracts: Cancer-inhibiting properties discovered in fucoidans

05 Dec 2017 --- Breakthrough research has confirmed that two unique compounds extracted from a specific seaweed have significant cancer-inhibiting properties. A series of animal studies undertaken at McGovern Medical School, University of Texas Health Science Center in Houston (UTHealth) have shown that the two fucoidans reduced tumor growth in select cancers and significantly improved the effectiveness of the common chemotherapy drug tamoxifen.

More Articles
URL : http://www.nutritioninsight.com:80/news/vitamin-k2-could-be-novel-therapeutic-target-for-common-cardiovascular-condition.html