Natural healthy aging and well-being solutions: Lemon and spinach extracts
04 Nov 2021 | Euromed
Mounting evidence suggests that the mostly plant-based Mediterranean diet may help cardiovascular, metabolic, digestive and cognitive health, as well as preventing frailty and visible signs of senescence in older people, therefore playing a key role in healthy aging. Euromed developed a line of Mediterranean fruit and vegetables extracts to provide some of the benefits of the popular diet in practical formats.
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Hello and welcome to today's nutrition insight webinar.
I hope all of our listeners tuning in have had a lovely week so far.
I'm Catherine Durrell, and I'll be moderating your webinar today.
I'm a platform editor at CNS Media, which is the publisher of The World of Food Ingredients, Food Ingredientsfirst.com, and NutritionInsight.com.
We are also the sister company of Enova Market Insights.
Before we get started, please note that you can submit your questions through the Q&A engagement tool, and if you don't get a chance to get to it during this session, it will be answered via email afterwards.
Additionally, this presentation will be available on demand on NutritionInsight.com, and a link to this will also be emailed to you.
Today's webinar is presented by Euromed and is entitled Natural Healthy Aging and -being Solutions, Lemon and Spinach Extracts.
It will delve into how Euromed's latest fruit and vegetable extracts can provide the benefits of the trendy Mediterranean diet in practical ways.
This mostly plant-based lifestyle has been associated with benefits of cardiovascular, metabolic, digestive, and cognitive health.
It has also been linked with preventing frailty and visible signs of senescence in older people, making it a very relevant approach for a world with a rapidly aging population.
That's all to come, but first, let's meet today's speakers.
Andrea Zangara is Euromed's head of scientific marketing and communications.
He brings over 20 years of international experience in pharmaceutical and nutraceutical research and development with positions in academia and the industry.
Notably, he's an author of over 30 research papers, review articles, book chapters, or books.
Also joining today is Freddie Silva Fuentes, Euromed scientific marketing technician.
He has 9 years of experience in clinical laboratory field, working in prestigious hospitals in Chile, focusing on quality control management and public health.
Before I hand over to them, I'd like to provide you with a quick overview of sustainability and health foods, drinks, and supplements using data provided by Anovo Market Insights.
Many consumers associate naturality with -being.
In a global survey, 41% of consumers selected natural ingredients as one of the five most important aspects of food and beverages.
It looks like the COVID-19 pandemic has also driven interest in naturalness and transparency, with the proportion of respondents who identify with these aspects a lot leaping by 11% points.
Notably, consumer interest in environmental claims were growing even before the pandemic, as we can see here in the jump from 2018 and 2020.
Today, the situation is that nearly 1 in 4 consumers would pay more for products that are sustainable or environmentally friendly.
On the right, we can see an example of how companies are leaning into this.
In this protein powder, the front features the word sustainable, while the back has a host of badges displaying various certifications.
It's also interesting to note that the powder is positioned as plant-based and Mediterranean diet approved, which will tie in nicely with the rest of the presentation.
Now that we have a sense of demands around naturality and the environment, let's hone in on wellness trends.
Consumers have a keen sense of food's impact on health, with 79% saying that eating foods that positively impact their health is an important method of staying healthy.
Therefore, it's no surprise that functional health claims are growing in food, drink, and supplement launches.
While digestive and gut health is still the most popular positioning, it's on track to soon be surpassed by energy and alertness, as as vitamin and mineral fortification.
Omega 3 and immunity claims are also on the rise, so they will be interesting to watch.
One key market today is the aging segment, with 2/3 of global consumers saying healthy aging is very important to them.
This is reflected in claims on F&B launches, which have seen 32% average annual growth.
As seen with this example on the right, one area of specific interest within healthy aging is bone health.
This formula features a bone density claim, along with aging positionings.
Across all these claims, it's crucial that companies provide evidence for their products.
More than 1/3 of consumers say that science and claims are more important than the way the healthy foods and beverages make them feel.
Here are 3 examples of product packaging that spotlights scientific backing.
On the left, this collagen powder uses the phrasing based on scientific evidence.
Next, this British supplement says that its vitamin C, D, and zinc are clinically proven to help strengthen the immune system.
Lastly, Max Yosa highlights key phrases like evidence-based, natural, and trust, right in red at the top, where consumers cannot miss it.
I hope this has all helped to give you a good basis for today's healthy aging market, and I'll now hand back over to Euromed.
Thank you, Catherine, for introducing and kickstarting the webinar and thanks to everyone that registered for this presentation.
The rest of the webinar ties up very nicely indeed with the Nova data presented by Catherine.
The raw materials for the Mediterranean fruit and vegetable extract are sustainably cultivated in southern Spain as shown in this clip, very close to the manufacturing plant, a state of the art facility where they are processed with an eco-friendly extraction, the pure hydro process, to obtain ingredients as natural as possible, providing some of the values of the Mediterranean diet, as we will see in the next slides.
Today, Euromed, now part of the Dermapharm Group, is a leading supplier of herbal extracts and natural active substances to global pharmaceutical, food, nutraceutical, and cosmetic industry.
This is our recently inaugurated four-story research and innovvention center in Barcelona, close to our main processing plant, an investment that we believe is proving our commitment to science and pharmaceutical grade quality.
To provide the highest quality, we have in place full traceability system and standardized procedures from the seeds to final extract.
This vertical integration, what we call traceability circle of excellence, helps to reduce some of the challenges of developing herbal medicines.
Nature is unpredictable, so potential challenges are in all steps of production.
A very different and more complex scenario than with synthetic molecules.
By controlling all the steps, we ensure documented traceability and consistency of different batches.
And provide custom therapeutic values of the extracts.
We start with botanicals that are verified, grown, and harvested properly to prevent, to preserve bioactive profiles.
The goal should be to gradually switch from wild harvest to sustainable plantations, but this is not yet possible with all plants.
In any case, we make sure that good agricultural and collection practices and local regulation are always fully implemented.
We are also expanding our range of organic extract, researching cleaner extraction methods, and prioritize locally sourced raw materials.
All our branded extracts are supported by extensive research plans to support claims and to support our customers' sustainable sales in the long term.
We also implement innovative ideas for waste management.
Here is a practical example.
So palmetto berries extracts are used for prostate health remedies such as our prosterol.
It is primarily a wild harvested the plant at risk of commercial exploitation and frauds, with many adulterated products in the market.
Authentic so palmetto grows basically only in Florida.
So in 2004, we built a licensed and certified dedicated facility right in the Everglades.
Processing and drawing the berries close to the collection point supports sustainable practices, provides complete traceability, and ensures optimal fatty acid content.
To make full use of this precious plant, our sopalmato waste materials are used for two natural-based dyes by Archroma for their herd colored line, upcycling natural waste materials and closing a cycle of intense labor.
Our Mediterranean fruit and vegetable extracts are grown in the Spanish region of Murcia, which is renowned for the quality of its fruits and vegetables near to Euromed manufacturing plant.
This state of the art facility used an eco-friendly proprietary extraction system developed more than 10 years ago by the Spanish firm Probelta Biotechnology, now part of the Euromed platform.
The eco-friendly pure hydro process is the modern version of a traditional extraction method similar to how we make an infusion with a tea bag.
It is based on physical procedures.
It starts with the aqueous processing of fruits with high purity osmatized water.
The aqueous solution is then filtered and purified using solvent-free techniques till a powdered extract is obtained with a ratio of active compounds similar as in the fresh fruit but more concentrated.
And completely eliminates the risk for residual content of volatile solvents in the extract and in the environment.
Food as a medicine is an ancient concept and one of the market concerns as reviewed by Catherine.
The Mediterranean diet, besides being very trendy and appealing, has evidence-based properties indicating a significant reduction in overall mortality, management of cardiovascular disease, diabetes, obesity, inflammatory disease, cognitive decline, and even cosmetic issues.
All these beneficial properties are mostly mediated by phytochemicals abundant in this plant-based diet such as the polyphenols.
While a Western diet promotes an age-related chronic increase in inflammatory status called inflammaging, the Mediterranean diet prevents or delays it with evident benefits for healthier age.
However, it may require eating several daily portions of fruit, vegetables, and olive a day, something that not everyone is willing or able to do.
In this context, there is a role for food supplements supported by safety and efficacy data.
As an example of a modern approach to the Mediterranean diet, as the title of a book I co-authored, Euromed R&D has investigated which botanical components of the Mediterranean diet are essential to its beneficial properties and identified so far pomegranates, olives, figs, artichokes, and now spinaches and lemon extracted with the pure hydro process.
Mita nuts is an olive fruit extract standardized for hydroxyyrozole, a polyphenol conferring olive oil its herd friendly properties.
However, intakes much larger than the 20 mL are required to reach the EFSA recommended 5 mg.
And this will go with additional calories.
Medicinox can provide this amount with just a few milligrams of the extract and is also available as a patented fortified extra virgin olive oil called Secrets to Leaf.
The extract delivers variable concentration of natural hydroxythrazole from 7 up to 40% and is supported by data on safety, efficacy, and long-term stability.
Clinical studies verified its antioxidant efficacy, and a recently published clinical study found that 8 weeks' daily intake of a precise combination of medicianox with our pomegranate extract.
Pomox.
Provided a significant beneficial effects on endothelial function, oxidized LDL cholesterol, and blood pressure in middle-aged participants.
A pre-clinical study with Pomanox proposed that its main mechanism of action in cardiovascular health consists of simultaneous increase in the synthesis of endothelium nitric oxide synthase, reduction of inflammation and oxidative damage.
More than 10 published studies corroborate its beneficial support in different health applications, mostly related with healthy aging and wellness.
For example, acute administration of Pomanox in healthy people improved significantly a number of cognitive tests and the cognitive performances associated.
And a 2 weeks Pamanox supplementation in trained cyclists increased sport performance and endurance.
The Mediterranean diet is gut-friendly, promoting healthy bacteria for digestive and microbiome support.
Euromed proposes Sinemet, a water soluble extract obtained from the edible part of the artichoke, which contains cafeolinic acids and inulin.
And the prebiotic properties of Sinemet have been tested with the SHM model which showed biphyogenic properties, so prebiotic properties.
So we proposed with Sinemet a holistic approach to digestive health, taking care of the whole digestive tract, as does the artichoke itself.
And for natural blood sugar control, the company developed Abalife, a fig extract with a standardized abscissic acid content.
Abscissic acid, or ABA, is a fascinating phytohormone with adaptogenic properties.
It's present in common foods, and figs contains high amounts of ABBA.
It seems crazy that the super sweet.
Fruit as the fig, may have something inside that reduced blood sugar, but a phase one clinical trial in healthy people demonstrated glycemic improvement, and a recently published pre-clinical study found that Ebola promotes glucose tolerance and insulin sensitivity whilst decreasing obesity-related systemic inflammation.
We now move to the most recent launches, starting with Spier, a spinach leaves extract with a standardized content of phytoactdisteroids, particularly 20 hydroxyeisone proposed for muscle function support.
Like abscisic acid, 20 hydroxeissone, or 20E, which is a much easier word to pronounce, possess quite extraordinary adaptogenic properties.
Ecdysteroids such as 20E are synthesized by many plants like spinach and quinoa, but spinach leaves are particularly rich in this plant sterile.
These compounds are vital to plant survival, as as invertebrates in which they control molting and metamorphosis it into another shape, in fact called ectasis.
In mammals, they have non-hormonal, anabolic, and adultrogenic activity through different pathways such as binding to estrogen, beta, and vitamin D receptors and activating the PI3 kinase AKT cellular growth pathway.
Supplements with these compounds are mostly marketed for bodybuilders and often either adulterated or not containing the amount originally.
The clinical evidence on muscle mass and strength is conflicting but suggesting a great potential in the perspective of muscle function and the process of aging.
At one end of this process and where Pisar is positioned, there is a slow progressive decline of strength, annoying but compatible with normal life, while at the other end, the decline in physical performance is more severe and even associated with physical disability, and this is defined as sarcopenia.
Age-related sarcopenia is a condition characterized by extreme loss of muscle mass, strength, quality, and low physical performance.
The European Group of sarcopenia and older people recently revised the consensus of definition and diagnosis, placing muscle strength as the primary parameter.
Muscle loss is now recognized to begin earlier in life.
From the age of 30, we start to see relative muscle loss, while from the age of 50, unfortunately, the muscle loss reduces up to 1% per year.
Muscle strength training, dietary intervention, and nutritional supplementation are the key preventive intervention interventions with particular emphasis on exercise.
So Spicer, together with exercise in 50 Plus, looked like an interesting approach to test in a clinical study.
A 12 week randomized double-blind placebo controlled clinical trial evaluated the effects of supplementation with spinach extract spicer on muscle function in adults older than 50 years of age.
This trial was recently conducted at the sports and nutrition department of the University of Murcia, and the study is currently submitted for publication, so I'm able to only show partial but hopefully convincing results.
The primary objective was to assess the efficacy of *** and muscle strength.
Secondary objectives included changes in body composition, quality of life, as as nutritional evaluation and assessment, safety.
The design of the study was with two parallel arms.
Eligible subjects were Caucasian men and women aged between 50 and 75 years with a BMI less than 32, and who did not participate in physical exercise on a weekly basis.
All subjects perform individualized and progressive exercises aimed to increase muscle mass, as this is one of the main properties of steroids suggested by literature.
One group received Spier 2 g per day in 4 capsules of 500 mg each, or a matching control that was maltodexin in 2 divided doses at the time of breakfast and lunch.
Participants were visited at baseline, visit 1 and at 90 days visit two or final visit.
45 participants completed the study, 23 in the experimental group and 22 in the placebo, and baseline characteristics were identical.
However, the balance between men and women was not equal with a large majority of women.
I believe they tried to compensate, but this was not possible.
And recruiting subjects during COVID restriction may have played a role.
It is also interesting to note, as highlighted in the slides, that the high percentage of participants fulfill criteria of sarcopenia.
The measures of the study were as follows.
Body composition measured by densitometry, muscle function and strength by isokinetic and isometric dynamometry of the legs.
Muscle quality was derived from the densitometry measures of mass, and perception of quality of life was measured with the SF 36 questionnaire.
Dietary surveys analyzed with specific software any potential influence of the diet.
However, changes were not expected as the subject had to maintain their current dietary habits, and safety was made evaluated with blood tests.
The physical training program was based on individualized and progressive polyarticular strength exercise involving the main muscle groups with moderate intensity, about 60-70% of maximum capacity.
And aimed to increase muscle mass as mentioned.
Supervised training was performed 3 days a week on alternate days, 1 hour per session, and in the same time slots.
For each exercise there were 10 repetitions for 3 series.
Exercises at each sessions were barbell squat with a guided bar, as in the drawing, and quadricep extension, lat pull-downs, and chest press using a multi-station weightlifting machine.
After finding the baseline training loads, they, they were adjusted every week according to the individual progress.
Now let's see the results.
Body composition was measured with the DEXAS test, which is an imaging technique that can measure main body components fat mass, lean mass, and muscle mass, and the lower limb, appendicular or leg dominant leg muscle mass was a measure derived from the DEXA scan and other measures taken during the study.
During the study, a decrease in the amount of body fats of the subject and an increase in muscle mass was observed, but these changes have occurred equally in both groups, as you see from the graphs.
So despite the fact that both groups modified significantly the values when measured by densitometries, this improvement cannot be associated with the consumption of the extract, but to the physical exercise program carried out.
When looking at the appendicular muscle mass of the lower limb, it can be observed that both groups start with similar values, but at the end of the study, only the experimental group had statistically significant value higher than at the beginning.
While supportive of the efficacy of the product, the comparison between the two groups was not significant.
So not very exciting results with the anthropometry measures, but things changed when we look at the results on strengths.
Muscle functional strength was measured with isometric and isokinetic leg dynamometry.
Concentric isokinetic extension of strength consisted of performing 5 maximum repetitions of knee flexion and extension angular velocities of 60 degrees and 80 degrees, 180 degrees per second.
The subject had to generate his maximum force values as fast as hard as possible.
Spitzer significantly improved muscle strength.
Assessed by isokinetic and isometric dynamometry.
It improved significantly over the placebo group.
The magnitude of improvement was higher, with significant between values difference in almost all variables, as you can see from these slides.
But let's have a look at some of these values more in detail.
For the peak torque of the knee extension at 60 degrees in isokinetic dynamometry, taking into account the progression of the two groups, while both showed significant improvement, Spitzer improved the torque peak for leg extension at 60 degrees, significantly more than the placebo as shown by the between groups key values.
For the peak torque of knee extension at 180 degrees in isokinetic dynamometry, no significant differences were observed for the placebo, but significant differences are observed with the SISA.
So when comparing the evolution of the two intake groups, significant differences were found.
For this reason, we can say that SISer increased this variable to a greater extent than placebo.
Isometric strength was assessed for the dominant knee.
The test consisted of performing the maximum force over a constant resistance and range of motion.
In this test, the dynamometer level did not allow the subject to move their legs, so the force had to be exerted as if they were trying to perform a full knee extension.
The force was maintained for 5 seconds with a rest between repetition of 30 seconds, and they had to perform 3 repetitions.
After a repetition as a warm-up.
Here again, both treatments improved isometric strength, but these are significantly more than placebo.
Muscle quality is defined as strength as as function.
It was calculated by dividing the muscle mass calculated by the DEXA scan, by the peak of the isometric test and the isokinetic test of the extension of the knee at 60 degrees of the dominant leg.
After the consumption of spicer for 12 weeks, the experimental group significantly improved muscle quality.
Very relevant data as muscle quality is a fundamental criteria for age-related muscle loss.
An additional analysis by gender was performed despite the differences in the ratio of men and women.
In women, improvements in muscle mass were similar in both study groups, although gains in muscle strength were superior in the spacer group than in the placebo.
In men, consumption of the active product induced higher increase in muscle mass, especially in the lower limb, than placebo, resulting in higher muscle strength and a greater increase in muscle quality.
Regarding quality of life, the SF 36 health questionnaire results indicated the use of both products, the placebo and Spicer, was associated with general improvements in the perception of health-related quality of life.
And significant within group differences were found for only two domains which were the role physical and role emotional, meaning the subject felt less limited in the usual role activities because of emotional problems and physical problems.
The interpretation of this result, I think it's basically that is the exercise that really is the key to improve quality of life.
So in terms of safety, the project was tolerated and laboratory results were all within normal range.
So to provide a summary of the results of the study, Consumption of both products significantly modified body composition as measured by DEXA scan with a decrease in fat mass and an increase in muscle mass.
Significant differences were found in the appendicular muscle mass, with an increase in the Spitzer group.
On the other hand, the total mass values of the participant are not modified during the time of the, trial.
A significant increase in the levels of strength.
Measured through the isometric dynamometry was observed when comparing Spitzer with placebo.
So Spitzer significantly improved strength.
Muscle quality was significantly improved by both the Spizer and the placebo, but is increased further in the Spier condition.
And there were potential differences by gender.
It seemed that muscle mass increased more in men and muscle strength increased more in women.
And physical exercise improves perceived quality of life in some dimensions more if Spizer is consumed.
So the conclusion are that Spier is a safe compound and may exert an all-body strengthening adaptogenic activity which may be beneficial for maintaining muscle function as we age.
This supplementation with Spier will be particularly useful for improving muscle strength and quality.
In the context of the prevention of the adverse muscle changes associated with advanced age together with physical exercise.
And now for Will Lemon, over to you, Freddie.
Hello to all.
My name is Freddie Silva Fuentes, and I work with Andreas Zangara in the scientific marketing department.
I always thank Andrea for giving me the opportunity to participate and explain about these wonderful new products that Eurome is developing.
Today I will be talking about one of our latest products presently launched in Vita Food, lemon, a water soluble lemon fruit extract.
While lemon is an, is an extract standardized in ostrin, a molecule belonging to the family of Cyprus flavono, and therefore it is important to understand what they are and to detail a little of the biochemical properties.
They are a group of flavonoid present mainly in citrus fruits, but can also be found in tomatoes and some other aromatic herbs such as mint.
A flabonon in the fruit is composed of a glycocyte in the green circle and the flabannon in the black circle.
And here we can see 33 examples of citrus flabannon, speridine and nareen, mostly found in orange and as I already mentioned, eriositin, that is the main flavonon in lemons.
The associated health benefits of citrus flabanon are documented.
There are a large number of publications at all levels detailing these properties.
They could be grouped academically speaking, in cardiovascular benefit.
Powerful antioxidant, anti-inflammatory, as a support to the Venus system.
Specially conditioned associated with venous insufficiencies, leg edema, among others.
And finally, also have an antimicrobial properties.
The pharmacokinetics for all these family of molecule is very complex, so they, so that they can reach our bloodstream and depend.
Of our intestinal microbiota.
To be transformed into a bioavailable compound.
Flagonos must be metabolized into glycos, the molecule without the sugar group, and for this, this large micromolecule must be taken by the gut microbiota.
And these are the ones that will carry out this process of metabolization.
Once this ugly con.
Are released into the intestinal lumen, it can be metabolized into other metabolized in the intestine or cross the gut barrier.
It is then in the bloodstream where it will reach the liver and produce all the secondary biomolecules that will exert the beneficial health effects or benefits.
But flabanons have a bioavailability issue.
Most of them are poorly soluble, and that is a major problem.
The first complication is that bacteria need a water-soluble compounds to take them up, and the second problem is that not all bacteria are capable to express glycosidase.
If both scenarios happen, all the desired effects are not fully achieved, as the unprocessed glycosylated flamannose will be excreted without exerting any beneficial effect.
With all this knowledge, Eurome has developed one lemon, a natural extract from a Spanish lemon standardized to 10% veriostri.
Its main characteristic is that ositri is almost 1000 times more soluble in water than the best known citrus flabannon on the market, asperity.
Therefore, and as we will see later, it has a great bioavailability that greatly exceeds asperity.
According to the evidence, Which we'll see later, are those of this product.
Of 100 and 300 mg is sufficient for exert health benefits.
It is important to note that one lemon is not a pure extract.
But thanks to its extraction process, explained by my colleague Andrea.
It creates a product rich in many other flavonoid compounds such as diosmethin or anarringenin, which indicate that one lemon is totally natural compound, just as if it were a lemon, but a concentration that allows, that allows us to take advantage of the various health benefits of this family of molecules.
But why is erositrine different?
Because of its molecular composition, this is a method of pure chemistry.
The basic structure is identical for all of them, and mainly the functional group of the bearine, where the molecules in the yellow and green circles are attached, varies.
As we can see, speridin has 1 hydroxyl and 1 methoxide group, and this gives it a solubility of only 5 picograms per microlitre.
Naringen has only 1 hydroxyl group which increased its solubility to an average of 40.
But oscirin, thanks to its two hydroxyl groups, also arranged in orthoposition, allows erositrin to have a water solubility of 4000 mcg per milliliter.
This is a gift to the bacteria, to the gut microbiota, and greatly increase the possibility that more bacteria with glycosidasis can take up.
Oscirin and metabolize it.
Another huge advantage in all this, it has been shown that the secondary metabolite.
And metabolized by oscitrine bacteria.
Ediotic to tends biochemically to metabolize intoperin as as following its own biochemical pathway.
However, asperritin does not tend to transform into eriotictal.
But follows its only own metabolic pathway.
All this metabolic process occurs mainly in the liver.
Based on this evidence, a clinical study organized by Ceva CEI in Spain was developed to compare the pharmacokinetics of one lemon with asperidine-rich orange extract.
The hypothesis was that the oscitrine is much more water soluble than asperidin.
And parin should be much more bioavailable.
This was a postprandial study.
A randomized double blind solver.
And The subjects were, were administered with an acute dose of 260 mg of standardized erositrine and speridin.
The study consists of testing each extract, and then the group took the extracts, first, the orange extract, and after 2 weeks, one lemon.
Controlling the diet, they were analyzed by a blood sample taken every hour to analyze the metabolites.
The results showed and confirmed the hypothesis and allowed the researchers to create a postulate.
And it was found that for the first time in humans, that eriositin cannot only produce its own metabolites.
But also a speridine metabolite.
This study showed that speridine can potentially produce up to 5 secondary metabolites capable of exerting health benefits.
Eosin, however, could produce a non-secondary metabolite plus the asperidine metabolite.
And this was really a success.
What the study finally concludes, consumption of one lemon, and eco-friendly erositron-rich lemon nectar, provide potentially efficacious circulating metabolite levels to produce health benefits, even in non-produced subjects.
Polemon helps overcome the latch by availability in intestinal glycons production, production due to the individual difference in microbiome composition.
Thanks to the high bioavailability of ostrin.
The health benefits that produce all the flavalos.
Will be the same.
As produced by Naringin or or speridin, for example.
Thanks to its high bioavailability and high solubility, The secondary metabolite of rheositri.
Are going to produce much more, more final health benefits such as cardio metabolic protection, antioxidant, inflammation support, venosystem support, and antimicrobial activity.
Than the ones that are produced by Narejin or speridin.
We must remember that the health benefit of all the Flabannons are the same, but it's very important, the capability of each Flabannon to get into our bodies.
If a molecule is completely insoluble, such as asperidin, All this molecule, once the subject intake is going to be completely excreted.
The case of oscitrin is completely different because the all the aforementioned.
It's going to produce way better health benefits.
And now back to me after Freddie gave you all the secrets of our extraordinary lemon.
But before concluding the presentation, I would like to give you a preview from our Mediterranean pipeline.
The next ingredient to be launched in the next few months is cuberra, a cucumber extract for joint health.
A clinical study just concluded and prepared for publication tested one capsule a day with 20 mg qba up or placebo for 8 weeks on joint pain in subjects diagnosed with osteoarthritis.
Primary efficacy endpoints was joint pain intensity measured with the visual analog scales.
Then the WOMA test measured pain and functional capacity and therefore a direct impact on quality of life.
The timed up and go test is a functional test to measure balance and mobility in patients with osteoarthritis of the knee, and isokinetic dynamometry, as seen before, measures strength.
And the inflammatory biomarkers were also checked during the study and also other biomarkers.
While I can't share yet the results, I can anticipate that most showed significant improvements.
So we believe this will be a powerful ingredient for joint health, and you will soon hear about it.
Thank you so much for this really engaging presentation.
So this is Catherine Durrell from CNS Media, and I'm back to host the Q&A engagement sessions.
I think there are a few questions already, so I'll let you guys take it from here.
We're going now to see a couple of questions and We have here one is the lemon extra standardized only to 10% erostry.
What is the rest of the composition?
OK, as Freddie mentioned in the presentation, Willemmon contains A lot of other bioflavonoids whilst the standardization for 10% of oscitrine is the key of the of the product as we understood the benefits and the extreme bioavailability and solubility of oscitrin is the combination of the all.
Compounds of the old bioflavonoids in the extract that actually provides the beneficial effects.
Another question related to a lemon, how do you relate to a lemon and a study with healthy aging?
It's a very good question, and to The most immediate reply I have is that during aging, there are changes in the microbiota and in our digestive tract that may influence the way in which we can make the most of the of the bioflavonoids and the metabolites of the bioflavonoids.
So if there is not a properly functioning.
Digestive system, the uptake of the compound and the successive metabolization into more bioactive metabolites may be impaired, and this is very likely happening during aging.
Besides the fact that all the properties of lemon are certainly suited for healthy aging, such as cardiovascular protection.
Circulatory issues, etc.
So we have a question regarding Pomanox.
The dosage of the pomegranate extract indicated was quite wide.
What does it mean?
Is it related to safety and efficacy?
Ammannox is extremely safe.
There is no risks shown in toxicology assessment, no side effect in clinical studies.
The ample dosage window, from 130 to 750 mg.
Indicated that at the lower end of the dosage, we start to see antioxidant and anti-inflammatory properties whilst at 750, we, we get the full effect as observed in the, in the cardiovascular studies, in the sports study, etc.
So basically it indicates dose dependent effects.
OK, so we have time for our last question, and this one is for the spinach extract.
Is Spier indicated for treating sarcopenia?
I wouldn't position Spitzer in the treatment of sarcopenia as mentioned in my slides, the, the, we position Spier more in the prevention of the age-related gradual decrease in muscle functions, which should be started early as a prevention.
So, while it whilst it may be of interest in sarcopenia.
I would not clearly identify the product as a treatment for sarcopenia.
So I, I wouldn't really, clearly defined bizarre for treating sarcopenia, but more as a sports nutrition for seniors.
That concludes today's Q&A session.
I'd like to thank everyone for tuning in to today's webinar brought to you by Euromed.
Before you continue your day, I'd also like to let you know that all questions that we didn't have time to answer today will be answered via email.
You can also check your inbox for an on-demand version of this presentation, which will be sent to you shortly.
And finally, you can keep up with the latest developments in nutrition news at nutritioninsight.com, where you can also sign up to our newsletters.
Have a good day.
