Oral ATP supplementation boosts muscular performance and prevents fatigue, research finds

A recent study sheds light on a potential breakthrough in exercise performance and recovery, suggesting that oral intake of adenosine triphosphate (ATP) could be a game-changer in preventing exercise-induced declines in ATP, which is the body’s primary energy currency.

The multi-patented Peak ATP is a clinically validated form of adenosine 5’-triphosphate (ATP) disodium, identical in structure to the ATP produced and used by the human body, and an energy source shown to improve muscle strength and blood flow. It is also a non-stimulant energy source.

Furthermore, the study found that this intervention improves peak power and muscular excitability. Muscular excitability, an important indicator of muscle function, is defined as the ratio of power output to muscle activation.

“Peak ATP is the only ingredient we know of that is proven to boost muscular excitability, a new and exciting category in sports nutrition,” says Larry Kolb, president of TSI USA.

“By boosting muscular excitability, Peak ATP provides a critical advantage to athletes who want to increase the intensity and/or frequency of their workouts and ultimately see better results from their efforts.” 

“Instead of fatiguing, athletes are able to push themselves harder because they are able to maintain muscle contractions during high-intensity workouts,” he adds. “That’s the beauty of this new ‘muscular excitability’ benefit from consuming Peak ATP pre-workout.”

Double-blind study

The research, a double-blind, placebo-controlled, randomized study conducted by the University of Tampa (US), involved forty-two healthy male participants.

For two weeks prior to engaging in repeated high-intensity sprinting bouts, subjects were given either 400 mg of ATP (patented Peak ATP supplied by TSI USA) or a placebo.

Key findings revealed that oral Peak ATP supplementation effectively prevented a drop in ATP, adenosine-5-diphosphate (ADP), and adenosine-5-monophosphate (AMP) levels following exercise.

It also prevented the decline of ATP in subsequent exercise bouts. Furthermore, the study demonstrated that ATP significantly increased Wingate peak power in later exercise bouts.

Kolb also emphasizes the direct support Peak ATP offers to the body’s natural ATP stores. He challenges, “If you want to support and replenish your body’s ATP levels, why not just take the real thing — Peak ATP —- instead of the many precursors out there that claim to boost ATP?”

Science backs oral ATP

This latest study, published in the Journal of the American College of Nutrition, contributes to the growing body of efficacy and safety research supporting Peak ATP as a crucial pre-workout ingredient for individuals aiming to increase muscle mass, strength, and power through enhanced muscular excitability, while also reducing post-workout muscle fatigue.

Last year, a systematic review and meta-analysis on the anaerobic power of Peak ATP analyzed the maximum strength and repetition capabilities of healthy subjects with resistance training. It concluded that oral ATP supplementation helps users achieve “significantly greater gains” in maximal strength safely compared with the placebo.

In July 2024, Peak ATP received an Informed Ingredient certification by LGC, ensuring that it has been tested for substances banned in sports nutrition products.