PLT Health Solutions launches joint mobility complex for cartilage health

PLT Health Solutions has released a new clinically backed ingredient, Kinexa Joint Longevity Complex, designed for lasting, foundational joint strength support. The ingredient is backed by a clinical study demonstrating how it improves the health of multiple joint structures. 

Kinexa is a patented combination of standardized extracts of haritaki (Terminalia chebula), turmeric (Curcuma longa), and Indian frankincense (Boswellia serrata).

The mobility supplement claims to help “whole-organ integrity,” enabling stronger knees for better joint stability. It also enhances cartilage matrix composition, improving cartilage thickness as well as shock-absorbing capacity.

“To date, most clinical work in the joint health sector has focused on enhancing comfort. But joints aren’t just ‘pain sensors.’ They are load-bearing mechanical systems,” explains Jeremy Appleton, director of Medical and Scientific Affairs at PLT Health Solutions.

“This new study on Kinexa is revolutionary because we are impacting a much broader range of factors that contribute to joint health and mobility.”

Jennifer Murphy, head of Innovation and Clinical Science at PLT Health Solutions, also highlights that Kinexa evaluates joints as a system, not just how they feel. “In this clinical study, we saw significant improvements in multiple measures of joint structure alongside functional outcomes, supported by advanced imaging.”

“That combination is rare in our category, and it opens the door for our customers to develop new products that may contribute to long-term mobility across different life stages. We are looking forward to engaging the health and wellness community on what joint longevity can mean when you measure the whole joint.”

Clinical research

A recent randomized, double-blind, placebo-controlled clinical study involved 100 subjects aged 40–75 with Grade II or III osteoarthritis, who received 200 mg/day of Kinexa or a matching placebo for six months.

Researchers assessed the ingredient’s effects at baseline, one, two, four, and six months. In particular, they studied how it affected pain management and physical function.

Results reported in this study include a 24% improvement in knee strength, 10% improvement in cartilage thickness, and an improvement of more than 26% in joint functional capacity.

These outcomes were tested using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale, and Lequesne Functional Index scores.

Functional measures included isometric knee torque, a six-minute walk test, and a timed “Get Up and Go” test.

The study incorporated advanced MRI imaging techniques that are not often utilized in dietary supplement research. These included quantitative and semi-quantitative measures of cartilage and whole-joint structural integrity, which comprises ligaments, menisci, subchondral bone, and synovium.

Researchers also evaluated the biomarkers of inflammation and cartilage metabolism.

Analyzing joint structures

According to PLT Health Solutions, the scope and “compelling nature” of the study’s results on Kinexa introduce “entirely new ways of thinking” about the joint health and mobility solutions market.

“Comfort is how the joint feels today; structure is what determines whether it keeps working years from now. Joint longevity is ultimately structural,” says Appleton.

“When cartilage, meniscus, ligaments, and the foundation beneath the cartilage stay strong and resilient, the joint can absorb shock, distribute weight evenly, and remain stable through everyday life, training, aging, and wear-and-tear.”

Results reported in this study include a 24% improvement in knee strength, 10% improvement in cartilage thickness, and an improvement of more than 26% in joint functional capacity.

The results displayed a 60% improvement in joint comfort, a 4.2% improvement in cartilage composition, and a 49% reduction in joint stiffness.

Additionally, the researchers observed increased glycosaminoglycan concentration in cartilage — indicating that the shock-absorbing properties of joints became more resilient — as well as enhanced ligament, meniscus, synovial, and subchondral bone health.

Other clinically supported joint health ingredients from PLT Health Solutions include its AprèsFlex five-day Joint Support. Backed by four clinical studies, AprèsFlex claims to deliver fast, low-dose support for joint comfort and cartilage health.

In 2025, PLT Health Solutions announced a new study on its Dynagenix Muscle+Joint Formula ingredient, which demonstrated that 40 mg/day of Dynagenix led to improvements in joint comfort, stiffness, and function as early as five days after initial supplementation.

Dynagenix is a low-dose B. serrata extract in a neutral-tasting, water-soluble form, which can be used in convenient delivery systems.