Botanic Healthcare’s Lipomac offers superior vitamin C bioavailability

New clinical data demonstrate the bioavailability of Botanic Healthcare’s Lipomac, a clinically engineered liposomal vitamin C developed with the company’s patented technology. The company states these findings demonstrate its liposomal vitamin C is an effective strategy for overcoming the “inherent absorption limitations” associated with conventional formulations.

The India-based supplier highlights that conventional vitamin C is susceptible to degradation in the digestive tract, limiting the amount that reaches circulation. 

The clinical trial with 12 healthy adults showed significantly higher systemic exposure after Lipomac supplementation, confirming enhanced absorption, improved gastrointestinal transit, and prolonged vitamin C circulation.

Dr. H. N. Shivaprasad, chief scientific officer of Botanic Healthcare, says: “These findings validate the core scientific engineering behind DFS Technology and reinforce the measurable performance advantages of liposomal formats.”

Liposomal delivery

The randomized, open-label, crossover clinical study compared the pharmacokinetics of Lipomac with conventional non-liposomal vitamin C in 12 adults, who were divided into two treatment sequences.

The liposomal formulation reached a higher peak plasma concentration than conventional vitamin C, with an approximately 2.36 times greater relative bioavailability. The researchers note this reflects improved absorption and systemic exposure.

“These results suggest that the liposomal delivery system markedly enhances vitamin C bioavailability, supporting its use for more effective therapeutic delivery,” details the study.

Botanic Healthcare explains that liposomal delivery systems use biocompatible phospholipid vesicles to encapsulate an active ingredient. As such, they enhance intestinal absorption, protect against chemical and enzymatic degradation, and improve delivery into the body’s circulation.

“These results suggest that the liposomal delivery system markedly enhances vitamin C bioavailability, supporting its use for more effective therapeutic delivery,” states the supplier.

Madhu Krishnamani, founder and managing director of Botanic Healthcare, adds: “The company is proud to advance health-focused solutions grounded in evidence and designed to deliver meaningful value to consumers worldwide.”

Stabilizing vitamin C

The company developed Lipomac using its proprietary DFS Technology. This patented platform is designed to stabilize sensitive active ingredients, enabling targeted delivery and maximizing biological performance.

Gaurav Soni, one of the company’s founders and managing directors, states: “Lipomac showcases the company’s commitment to clinically backed innovation and strengthens its position as a science-forward partner to global nutraceutical brands.”

Lipomac is part of Botanic Healthcare’s Lipsobio portfolio of liposomal ingredients with vitamins, minerals, nutraceuticals, and botanical actives.

Each ingredient in this range is authenticated through high-resolution imaging techniques, nanoscale structural mapping, stability and encapsulation profiling, in vitro absorption experiments, and clinical data.

Last year, Nutrition Insight discussed how liposomal technology has taken hold in Southeast Asian supplements with Wooree at Vitafoods Asia. The South Korean company spotted a rising use of the delivery system in nutraceuticals, while it was initially developed for drug delivery.

Meanwhile, we met with the author of a recent study showing that eating vitamin C-rich foods raises skin vitamin C levels and supports collagen production more effectively than through topical products.