Studies show Nutratech's Advantra Z(R) to be safe and effective

09/09/05 Two recent scientific studies - conducted at McGill Nutrition and Food Science Centre and University of California, San Francisco (UCSF) - have shown Advantra Z(R), Nutratech's proprietary Citrus aurantium (bitter orange) extract for weight-loss and sports nutrition markets, increases resting metabolic rate and has no impact on blood pressure, respectively.

In "Synephrine Pharmacokinetics and Cardiovascular Changes after Ingestion of Citrus Aurantium Dietary Supplements," Christine Haller, M.D., a fellow in medical toxicology at UCSF, conducted a randomized, double-blind, placebo-controlled study utilizing Advantra Z as the synephrine source. Researchers noted that while they believe "ephedra-free weight loss dietary supplements have significant cardiovascular stimulant actions ... these pressor effects are not likely caused by Citrus aurantium." The study says even in eight-fold higher dosages, Advantra Z had no effect on blood pressure. Dr. Haller's study was presented at the annual meeting of International Journal of Clinical Pharmacology and Therapeutics and published in September's American Journal of Medicine.

Dr. Haller's findings echo results from independent laboratory Chromadex, which recently found Advantra Z contains the stable p-isomer of synephrine, not m-synephrine, which has the potential for raising blood pressure.

The study determined that thermic response to Citrus aurantium was higher in men when taken alone and more efficacious for women when added to a meal. The report notes, "Citrus aurantium had no effect on blood pressure and pulse rate...."

Based in Wayne, N.J., Nutratech, Inc., provides innovative, proprietary and patented nutraceutical ingredients to the dietary supplement, weight management, sports nutrition, beverage and food industries.

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