Researchers uncover how dietary fiber fuels gut health maintaining cells

11 Aug 2017 --- Researchers at UC Davis Health have discovered how by-products of the digestion of dietary fiber by gut microbes act as the right fuel to aid intestinal cells in maintaining gut health. The findings are significant because they identify a potential therapeutic target for rebalancing gut microbiota, adding to a growing body of knowledge on the complex interplay between gut microbiota and dietary fiber.

The research was published in the journal Science, and an accompanying Insights / Perspectives article in the same issue describes gut microbes as “partners” in the body's defense against potentially infectious agents, such as Salmonella.

According to Andreas Bäumler, professor of medical microbiology and immunology at UC Davis Health and senior author of the study, the research suggests that feeding the beneficial microbes in our intestines dietary fiber, their preferred source of sustenance, may be one of the best approaches to maintaining gut health.

“While it is known that the gut is the site of constant turf wars between microbes, our research suggests that signals generated by beneficial microbes drive the intestinal tract to limit resources that could lead to an expansion of potentially harmful microbes,” he says.

Resident gut microbes metabolize indigestible dietary fiber to produce short-chain fatty acids, which signal cells lining the large bowel to maximize oxygen consumption, thereby limiting the amount of oxygen diffusing into the gut lumen (the open space within the intestine that comes into direct contact with digested food.)

“Interestingly, the beneficial gut bacteria that are able to breakdown fiber don't survive in an environment rich in oxygen, which means that our microbiota and intestinal cells work together to promote a virtuous cycle that maintains gut health,” says Mariana X. Byndloss, assistant project scientist and first author on the study.

The new research identified the host receptor peroxisome proliferator receptor gamma (PPARg) as the regulator responsible for maintaining this cycle of protection.

“When this host signaling pathway malfunctions, it leads to increased oxygen levels in the gut lumen,” Bäumler says. “These higher oxygen levels make us more susceptible to aerobic enteric pathogens such as Salmonella or Escherichia coli, which use oxygen to edge out competing beneficial microbes.”