Probiotic use associated with fewer antibiotic prescriptions: study

20 Sep 2018 --- Healthy infants and children who take probiotics as a preventative measure receive fewer antibiotic prescriptions, a scientific paper published in European Journal of Public Health reports. The findings are of particular interest considering the growing global demand for ways to reduce antibiotic use, given the urgent public health threat of antibiotic resistance. 

Authored by an international group of ten scientists, the paper reviewed studies that administered Lactobacillus or Bifidobacterium to healthy people to determine the impact of probiotics on incidence or duration of common infectious diseases. 

In all studies that also tracked antibiotic use, the study found that healthy infants and children who consumed probiotics rather than a placebo were at least 29 percent less likely to receive or consume antibiotics. No studies in adults were included because these studies did not track antibiotic prescriptions.

“Taken together, the studies we included in this analysis demonstrated that probiotic supplementation is more effective than placebo for reducing the incidence or duration of certain illnesses: acute respiratory tract infections, acute digestive infections, and acute ear infections,” says author Andi Shane MD MPH, Emory University School of Medicine. “This analysis shows that, in addition to those advantages, probiotic supplementation may reduce the use of antibiotics.”

The authors note that this reduced antibiotic prescribing may occur because probiotics reduce incidence and duration of infections. If people stay healthy or get healthy sooner, antibiotics may not be prescribed. Alternatively, probiotics may serve as a tool physicians use as a replacement for antibiotics for self-limited illnesses that don't require antibiotics.

The authors emphasize that follow-up studies are needed in all age groups, investigating the probiotic formulation and dose that may be the most effective.

Previous analyses show a high prevalence of unnecessary or inappropriate antibiotic prescriptions – contributing to the critical public health threat of antimicrobial resistance. 

“This publication is proof-of-concept that taking probiotics on a regular basis deserves consideration as a way to reduce the over-prescription of antibiotics,” says Prof. Daniel Merenstein MD, Georgetown University School of Medicine. 

“Given the potential public health risks of widespread antibiotic misuse, innovative strategies for addressing this problem are urgently needed,” he adds.

The analysis was initiated by a working group that met at a 2016 meeting of the International Scientific Association for Probiotics and Prebiotics (ISAPP).