Arjuna Natural finds withanolide glycosides boost ashwagandha’s bioavailability

Arjuna Natural finds that withanolide glycosides are linked to increased bioavailability of ashwagandha extracts. The manufacturer touts this as the first direct evidence in humans to show that not just the content but also the type of these compounds changes absorption and efficacy.

Its randomized, open-label, crossover study examined four commercially available ashwagandha extracts with different compositions, including Shoden standardized to 35% Withania somnifera withanolide glycosides, along with extracts containing 10%, 5%, or 2.5% W. somnifera withanolide glycosides.

“Clinical data now confirm that withanolide glycosides stand out not just for quantity but for quality, with higher bioavailability than other withanolide types,” reveals Benny Antony, Ph.D., joint managing director of Arjuna Natural. 

“Our findings suggest that the strength of ashwagandha is in its withanolide profile, specifically the chemical nature of the withanolides — and not their total amount. This plays a critical role in determining the uptake and metabolism of ashwagandha extracts in the body for optimal effect. This study emphasized the importance of extract composition and the plant parts used.”

Finest quality

The publication in Current Therapeutic Research checked for ashwagandha’s bioavailability in 16 healthy human volunteers. They took ashwagandha with Shoden standardized to 35% W. somnifera withanolide glycosides.

Arjuna Natural points out that Shoden is a highly bioactive extract of ashwagandha, having 35% active compound withanolide glycosides from validated ashwagandha sources.

Researchers used 17 blood samples to examine quantities of plasma concentrations of withanolide A, withanoside IV, withaferin A, and total withanolides. They also calculated pharmacokinetic parameters, which show how a substance is metabolized over time.

Pharmacokinetic profiles were significantly different, revealing that plant-sourced withanolide glycosides in extracts have a higher systemic exposure.

Indian medicine for rejuvenation

Ayurvedic medicine has used ashwagandha, also known as the Indian ginseng, as a “rasayana” — for rejuvenation. Clinical studies have proven its ability to boost resilience and vitality and promote longevity, and mental wellness.

The botanical also provides antioxidant, anti-inflammatory, and immunomodulatory properties, adds the company. However, Withania extracts in the market are notably different in their active compound profiles. Including analytical methods, plant parts used, manufacturing processes, and recommended dosages, which can affect therapeutic benefits.

Commenting on the latest findings, Antony says: “These findings have major implications for both consumers and supplement manufacturers. As ashwagandha continues to gain popularity for its adaptogenic, cognitive, and stress-relieving benefits, the current research underscores the need for more detailed labeling and standardization that goes beyond total withanolide content.”

“Future clinical studies and product formulations should consider the specific withanolide profile — particularly the presence of glycosides — to deliver ashwagandha extracts with maximum efficacy and consistency.”

Recently, Arjuna Natural revealed its clinically studied Ashwagandha extract, Shoden, received Non-GMO Project Verification. Earlier this year, Health Canada endorsed Arjuna’s Shoden for reducing stress and as a sleep aid.