Study Uncovers Hard Data on Food Allergies

01 Jun 2017 --- Research has found that 3.6 percent of people had a documented food allergy, with highest rates among females and Asians. Investigators from Brigham and Women's Hospital combed through medical records from more than 2.7 million patients, identifying more than 97,000 with one or more documented food allergy or intolerance. Their findings are published in the Journal of Allergy and Clinical Immunology.

"Recent reports suggest that food allergies are on the rise, with more food-allergy related hospitalizations in the US over the last decade. However, many studies have been based on telephone surveys or have focused on a specific food allergen or allergen group," says Li Zhou, MD, PhD, of the Division of General Medicine Primary Care at BWH. "We recognized that the electronic health record system could offer a treasure trove of information about allergies to better understand which populations may be most affected and just how common food allergies and intolerances are in the US."

Some of the team's findings include:

• Food allergy or intolerance were documented for 3.6 percent of the population studied
• Shellfish was the most commonly reported food allergy
• The highest rates of food allergies or intolerance were among females and Asians

The multidisciplinary team, including a medical student, Warren Acker; an allergist, Kimberly Blumenthal, MD, MSc; patient safety experts and informaticians, used food and allergy intolerance data collected at Partners HealthCare between 2000 and 2013, including information from multiple community and specialty hospitals as well as community health centers. The team examined data on culprit foods, reaction(s) to that allergen, date/time of the reaction and more. 

The research team used the term "food allergies and intolerances" to include any adverse reaction to food (such as hives, anaphylaxis, shortness of breath, wheezing, itching, swelling and more) as well as pseudoallergic reactions, intolerances and even food preferences reported in the health record.

The team looked at a variety of food allergens, finding that almost 13,000 patients had a reported allergy or intolerance to peanut, including more than 7,000 (56.5 percent) who had hives, anaphylaxis, or other potentially IgE-mediated reactions. To better understand the validity of the food allergy data they examined, they looked at specific antibodies produced in response to peanut via the radioallergosorbent test (RAST) or ImmunoCAP test for all patients who reported a peanut allergy.

The overall rate of allergy prevalence that the team found -- 3.6 percent -- is consistent with previous estimates using oral food challenges.

The team also notes that food allergies are quite common but there are fewer than 7,000 allergists/immunologists in the US; these data suggest the US does not have the capacity to evaluate/confirm allergies for all patients who initially test positive (only 1 in 5 patients with a peanut allergy received follow-up allergy testing). Food allergies are estimated to cost the US US$25 billion annually.