Soy protein could help reduce effects of diabetes on liver

08/09/05 A group of researchers from Mexico has discovered that a diet rich in soy protein may alleviate fatty liver, a disease which often accompanies diabetes. The details of their findings appear in the September issue of the Journal of Lipid Research, an American Society for Biochemistry and Molecular Biology journal.

The high levels of insulin and insulin-resistance that accompany diabetes are often associated with fatty liver or hepatic steatosis, an untreatable condition that can lead to chronic liver disease and death. In this condition, large lipid-filled compartments accumulate in the cells of the liver due to an increase in production of fatty acids in the liver. The end result is an enlarged liver.

Following up research that indicated that eating soy protein reduces lipid production and prevents hyperinsulinemia (the loss of effectiveness of insulin), Dr. Nimbe Torres, of the Instituto Nacional de Ciencias Medicas y Nutricion in Mexico, investigated the effects of a diet high in soy protein on the development of fatty liver associated with diabetes.

Dr. Torres fed Zucker diabetic fatty rats that develop hyperinsulinemia and hepatic steatosis a diet of soy protein for 160 days. She found that the consumption of soy protein prevented the accumulation of triglycerides and cholesterol in the liver despite the development of obesity and hyperinsulinemia in the rats.

In addition, levels of a transcription factor involved in controlling genes involved in fatty acid breakdown, as well as its target genes, were increased in rats fed soy protein. Thus, feeding rats a soy-rich diet reduced the amount of fatty acid in their liver by not only reducing lipid production but also by increasing its breakdown.

Although further research is needed, Dr. Torres believes that consuming soy protein could very well reduce insulin resistance, renal damage, and fatty liver, improving quality of life.