Microbiome Found to Play a Role in Regulating Fear Responses

17 May 2017 --- The microbiome, the collective trillions of bacteria within the gastrointestinal tract, regulates fear responses and modifies the brain function of adult mice, new research, from scientists at the Science Foundation Ireland-funded APC Microbiome Institute at University College Cork, has shown.

The research shows, at least in animal models, that major disturbances in communication between the gut microbiota and brain underlie fear memory recall and also modify molecular pathways in the amygdala, the brain region key to the expression of anxiety and social behaviors.

Using microbe-free mice, Professor John F. Cryan and Dr. Gerard Clarke, along with their Ph.D. student Alan Hoban, have shown that growing up in a germ-free bubble results in blunted fear responses. Importantly, the team was able to show that at a molecular level the amygdala of these microbiota-deficient animals was in a hyperactive state.

Fear is a normal response that allows an individual to deal with an impending threat in the environment. The neurobiology of fear is evolutionarily hardwired and tightly regulated by the amygdala. Understanding the factors that regulate fear and fear-associated memories is an important step towards developing therapies for disorders where excessive brain responses to fear memories are manifested, such as post-traumatic stress disorders (PTSD).

Over the past decade, it has become increasingly clear that the microbiome plays a clear role in our health and wellbeing. Perhaps most surprising of all is the realization that gut bacteria influence brain function and behavior.

Although, more work is needed to advance our understanding of the mechanisms behind the relationship between the microbiota and fear responses Prof Cryan says that “it is likely that key signals from the gut to the brain act as regulators of the fear response”. Furthermore, he says that “understanding what these mechanisms are may open up the use of innovative microbiome-based strategies for tackling fear-related disorders.”

“Our data show the microbiome is critical for normal fear responses, but it is just the start; we are now searching for strategies to target the microbiome to generate novel efficacious treatments for anxiety disorders such as PTSD,” Dr. Clarke says.

Translating these data from bench to bedside opens up the tantalizing prospect of targeting the microbiome to treat fear-related disorders. Moreover, this data presented by the APC Microbiome team continues to broaden the concept that the microbiome has a remarkable influence over fundamental brain processes and may be harnessed in the future for a wide range of brain disorders.

Their research is being published in the high impact Nature Journal Molecular Psychiatry and was supported by Science Foundation Ireland through a grant to the APC Microbiome Institute and by the Brain and Behaviour Research Foundation.