Hot Pepper Ingredient Shown to Possess Fat Burning Properties

Twenty subjects - 10 men and 10 women - participated in the randomized, double-blind, placebo-controlled, crossover study, comparing the result of 100 mg of Capsimax or a placebo.

Oct 12 2010 --- Results announced from a study undertaken at the University of Memphis by Bloomer et al published in Lipids in Health and Disease found the proprietary hot red pepper extract Capsimax from OmniActive to promote a lipolytic effect as measured by an increase in free fatty acids and glycerol in blood compared to placebo.  In addition to demonstrating this beneficial effect, Capsimax had no adverse impact on heart rate, systolic or diastolic blood pressure.  There were also no observed side effects related to gastric upset or discomfort despite the fact that individuals fasted for 12 hours prior to the supplementation.

Twenty subjects - 10 men and 10 women - participated in the randomized, double-blind, placebo-controlled, crossover study, comparing the result of 100 mg of Capsimax or a placebo.  Upon overnight fasting for more than 12 hours, subjects were given either Capsimax or a placebo.  Blood samples were then taken during each visit at various time-points: 30 minutes pre-ingestion; 2 hours post ingestion of either Capsimax or placebo (2 hour); one minute following the cessation of 30 minutes of exercise (2.5); and 90 minutes after exercise (4 hour).  Heart rate, systolic and diastolic blood pressure were measured at all blood collection times in addition to catecholamine data and free fatty acids and glycerol values.

The following were the results/findings:
• No observed side effects related to gastric upset or discomfort in the 4 hours after ingestion, even after a 12 hour fast.
• Plasma free-fatty acids increased after ingestion at 2 hours (pre-exercise) and 2.5 hours (post-exercise) compared to placebo.
• Plasma glycerol concentrations increased significantly 4 hours after ingestion.
• Capsimax at 100 mg did not adversely affect heart rate, systolic or diastolic blood pressure.

Capsimax in combination with exercise was seen to help increase plasma free fatty acid concentration and glycerol compared to a placebo under the same conditions. These higher levels of free fatty acid levels and glycerol indicate lipolytic activity due to the capsaicinoids present in Capsimax. "Lipolysis" is a process where fat cells break down the triglycerides present within them into glycerol and free fatty acids.  An increase in lipolysis may offer improved chances of weight control.

"This study shows very promising results surrounding Capsimax's ability to help burn fat, while substantiating the need for supplementation with Capsimax in combination with exercise. We are pleased to be adding to findings of an earlier study where Capsimax Plus Blend supplementation combined with exercise showed higher levels of calories burned. Both studies revealed positive results for these key components to successful weight management ” stated Jayant Deshpande, Ph.D., Chief Technology Officer, OmniActive Health Technologies, Ltd. "Findings also confirm that Capsimax can effectively be used in formulations for weight management and sports nutrition." 

Capsimax Capsicum Extract is a proprietary encapsulated form of premium, highly concentrated natural capsicum fruit extract manufactured from hot red peppers, a known food that has been a global diet staple for centuries. Capsimax utilizes the innovative and patented encapsulation technology OmniBead to deliver functionally effective levels of the active principles of capsicum - capsaicinoids - while minimizing the oral and gastric irritation often experienced with unprotected hot red pepper product applications.  Research in both animal and human subjects on capsicum and capsaicinoids has indicated significant effects for diet and weight management including increased energy expenditure, enhanced carbohydrate and fat burning and reduced caloric intake.  Capsimax is formulated to meet diverse formulation and manufacturing requirements and is ideal for use in nutritional supplements for weight management, diet control and sports nutrition.