Bioiberica unveils clinical evidence backing Collavant n2 native type II collagen

New clinical evidence has found that type II collagen supports articular cartilage in healthy individuals with activity-related joint discomfort. The trial was conducted by Bioiberica on its Collavant n2 — a native (undenatured) collagen — and the benefits were shown when supplementing with 40 mg per day. 

This is the first time this effect has been demonstrated in healthy subjects, which may lead to new products tailored to active, health-conscious consumers seeking proactive joint support.

“Previously, we demonstrated that Collavant n2 supported faster recovery and functionality in active individuals,” says Daniel Martínez-Puig, one of the lead scientists of the study and head of R&D Human and Animal Health at Bioiberica.

“Now, we have evidence of its effects at the cartilage level through the reduction of CTX-II, a byproduct of type II collagen degradation, considered one of the most tested and validated biochemical markers of cartilage degradation.”

Six-month results

Bioiberica’s Collavant n2 is derived from chicken sternum, fully sourced and manufactured in Europe and backed by seven scientific studies.

For six months of the study, healthy individuals experiencing joint discomfort during exercise supplemented with 40 mg per day of the ingredient. Researchers measured the participants’ urinary CTX-II concentration, a key biomarker of collagen degradation and cartilage breakdown.

Bioiberica’s Collavant n2 is derived from chicken sternum, fully sourced and manufactured in Europe and backed by seven scientific studies.

Participants taking Collavant n2 experienced an 18.3% reduction in CTX-II levels, while those in the placebo group showed a 20.6% increase.

“These findings add to existing evidence demonstrating that Collavant n2 not only helps reduce exercise-related joint discomfort but also supports mobility, quality of life, and cartilage health at the structural level,” states Bioiberica.

“The ingredient’s targeted mechanism of action, known as Oral Tolerance, enables the body to modulate the immune response against its own type II collagen.”

Verification and scientific backings

Collavant n2 is the first collagen to become NutraStrong Collagen Verified, a program developed by SGS Nutrasource, and endorsed by the Collagen Stewardship Alliance. The certification assures its position as a credible, high-quality ingredient for joint health innovation.

The ingredient was also shown in previous scientific research to reduce osteoarthritis symptoms in five days when taken in combination with the herbal extract Boswellia serrata.

To more broadly share insights across the collagen sector, Bioiberica established the Collagen Symposium, an initiative to convene industry experts to discuss the future of the market, key challenges, and opportunities.

On the company’s 50th anniversary in June, Nutrition Insight toured its manufacturing site in Palafolls, Spain, and sat down with Bioberica’s Luis Solera, CEO, and Antonio Vendrell, marketing and communications director, to discuss new product development directions.