07 Feb 2018 --- In mice, fructose is processed mainly in the small intestine, not in the liver as had previously been suspected, Princeton University researchers report. However, sugary drinks and processed high-sugar foods may overwhelm the small intestine and spill into the liver for processing. Additionally, the authors note that the ability of the small intestine to process fructose is higher after a meal. Although the study was conducted in mice, the researchers recommend "the most old-fashioned advice in the world" for humans: Limit sweets to moderate quantities after meals, and do not have sweet drinks away from meal time.