Maintaining muscle health: HMB emerges as science-backed sarcopenia solution

As the global population ages, maintaining muscle health and strength has become a critical public health priority — particularly for adults over 50. Two recent scientific reviews bolster the case for HMB (β-hydroxy β-methylbutyrate) as a proven, science-backed nutrient that supports muscle mass, strength, and physical function in older adults.

HMB, a naturally occurring compound derived from the amino acid leucine, has been shown to stimulate muscle protein synthesis and reduce muscle breakdown. TSI Group, creators of MyHMB, stress that these dual actions make the ingredient a valuable tool in preventing sarcopenia — the progressive loss of muscle mass and function that affects millions of aging individuals.

“Consumers are increasingly looking for proactive solutions to stay strong, mobile, and independent,” says TSI Group’s vice president of business development, Shawn Baier. “Brands must meet this shift head-on. Ingredients such as HMB, with clinically confirmed benefits, offer an incredible opportunity to deliver meaningful support to the 50+ demographic.”

“This new meta-analysis validates what we at TSI have been championing for years — HMB is a scientifically proven ingredient that supports muscle health and function as we age. We’ve long understood the critical role HMB plays in addressing age-related muscle loss, and it’s rewarding to see the clinical community continue to affirm that.”

Recent findings

A meta-analysis published in Frontiers in Nutrition evaluated data from 21 randomized controlled trials involving 1,935 participants aged 50 and older. The study found that HMB supplementation significantly improved muscle health outcomes, with the strongest results at a daily dose of 3 g over at least 12 weeks. The findings offer clear guidance for clinicians and product developers looking to support aging populations.The studies recommend supplementing 3 g of HMB daily.

A second review in Nutrients highlighted HMB’s strategic role in managing sarcopenia, which is now formally recognized as a disease. The review emphasized that HMB supplementation could be a key component in clinical nutrition protocols for older adults.

“HMB may be an effective supplement for maintaining muscle mass, strength, and function, particularly in the elderly and in patients experiencing conditions that predispose them to muscle loss, such as chronic diseases, physical inactivity, or aging,” the researchers note.

Getting the correct dosage

The studies reveal that a 3 g daily dose of HMB is practically impossible to achieve through diet and suggest that taking the right amount of HMB is important to boost muscle growth and prevent muscle breakdown, especially for treating sarcopenia or helping muscles recover.

TSI Group highlights that HMB is emerging as a pivotal nutrient for brands and healthcare providers focused on healthy aging due to its strong scientific backing and growing demographic need.

“At TSI, we believe innovation means staying ahead of the curve while also ensuring the science stands behind the story,” Baier concludes. “HMB is no longer just a promising ingredient. It’s a proven solution for one of the most pressing health challenges of our time: preserving muscle and quality of life as we age.”