29 Nov 2022 --- Maternal weight may significantly contribute to adverse neurobiological effects in offspring, according to new research from Duke University, NC. The study focuses on how a maternal high-fat diet causes endotoxin accumulation in fetal tissue, with subsequent inflammation causing sex-specific neuropsychiatric disorders.“Bulk sequencing from a large cohort of matched first-trimester human samples reveals sex-specific transcriptome-wide changes in placental and brain tissue in response to maternal triglyceride accumulation (a proxy for dietary fat content),” says the study.
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