Probiotic and Fiber Combination Can Reduce Body Mass

03 Nov 2016 --- The probiotic Bifidobacterium animalis ssp. lactis 420, alone or in combination with the prebiotic fiber Litesse Ultra polydextrose can reduce body fat mass, trunk fat mass, waist circumference and energy intake, according to a six-month, double-blind, randomized, placebo-controlled study published in EBioMedicine.

225 subjects consumed either Placebo, microcrystalline cellulose, 12 g/d, the prebiotic fiber Litesse Ultra polydextrose, 12 g/d, DuPont proprietary strain of probiotic Bifidobacterium lactis 420, 1010 CFU/d in microcrystalline cellulose, 12 g/d, or the combination of the prebiotic fiber and the probiotic strain.

Both the probiotic and synbiotic products helped control body fat mass, leading to an approximately 1.4 kg difference compared to placebo in those participants who adhered to the study protocol.

However, only the consumption of the combination of Bifidobacterium lactis 420 with Litesse Ultra polydextrose led to improvements in lean body mass. It also demonstrated reduced energy intake during the trial and reduced waist circumference.

The overall results demonstrated that the probiotic and synbiotic (fiber plus probiotic combination) seem to control body fat mass, especially in the abdominal area in overweight adults.

“The potential influence of the gut microbiota on the regulation of body weight and shape is an exciting area right now,” said Megan DeStefano, Probiotics global marketing lead at DuPont Nutrition & Health.

“Around the world, consumers are seeking natural support for weight management. In DuPont proprietary market research, we have identified that 57 percent of the global population are confused about what they should eat and what will help them achieve weight goals without making major lifestyle changes.”

“We believe this product will give our customers a great market opportunity,” notes DeStefano.

The volunteers in the study were randomized into one of four groups and asked to consume the study product daily for 6 months.

“This is the first study to translate findings from studies of the probiotic strain Bifidobacterium lactis 420 done in animal models in which it was shown the probiotic can improve metabolic health in mice by strengthening gut barrier function,” said Lotta Stenman, Ph.D., lead investigator on the preclinical and clinical trials, with DuPont Nutrition & Health.

“There is a long history of research on this particular probiotic strain, starting from initial findings from cell culture studies published in 2008. It is exciting to see the extensive preclinical and mechanistic work paved the way for identifying a benefit to human health.”

DuPont Nutrition & Health will continue to conduct research on the role of probiotic and prebiotic supplementation on gut microbiota and outcomes related to obesity and metabolic syndrome, conditions that currently affect over a third of the global population.