05 Mar 2019 --- Stevia-based sweeteners have no impact on the gut microbiome, according to new research from Biopharmaceutical Research Inc. (BRI) and funded by sweeteners producer PureCircle. The in vitro study showed that the gut bacteria of men, women and children who consumed PureCircle’s new generation stevia leaf sweeteners, such as Reb D and Reb M, remained comparably the same over a 72-hour metabolic incubation period. The study adds to the growing body of evidence supporting that low-calorie sweeteners have no adverse effects on health.