Females' “healthier fat” protects them from obesity-related health issues, mice study finds

636759697086305350woman scales weight.jpg

24 Oct 2018 --- Female abdominal fat, in mice, has more blood vessels than males' which may explain why males and females differ in susceptibility to cardiovascular disease, insulin resistance and diabetes, notes research from York University, Canada. Previously, it was noted that female fat tissue tends to be more protective against health issues, such as diabetes and cardiovascular disease, than male fat tissue but the underlying reasons were not understood. Understanding the underlying mechanisms behind sex differences in cellular processes are important as they may contribute to individual's susceptibility to develop serious health issues.

“We found that female mice have a higher number of blood vessels in their fat than males and that females increase the number of blood vessels as they are fed a high-fat diet, while males do not. We concluded that this response enabled females to maintain healthier fat and better insulin sensitivity as they grew fat,” says Tara Haas, a Professor in the School of Kinesiology and Health Science, Faculty of Health.

Blood vessels are critical for maintaining healthy fat tissue by ensuring that the expanding fat cells are supplied with enough oxygen and nutrients, so the researchers looked at whether the abilities of the fat tissue to grow blood vessels and maintain healthy fat tissue would be different between males and females.

The sex differences in the fundamental cellular processes that regulate the growth of blood vessels were unappreciated in the past, says Haas. It is important to understand them because they may contribute to an individual's susceptibility to develop serious obesity-related health complications such as diabetes, heart disease and cancer, ultimately impacting the health of more than 5.3 million Canadian adults.

Martina Rudnicki, a York post-doctoral Associate and first author of the study, pointed out that the study, published in Frontiers in Physiology – Vascular Physiology, was unique because it focused on the differences in male and female fat tissue in the abdominal area. 

Although fat accumulates in different regions of the body, it is abdominal fat that is closely linked with increased risk of developing diabetes, particularly in males. So, the fact that females grow new blood vessels in this abdominal fat during weight gain may exert a health advantage for females.

The research team plans to confirm these findings in human samples. While it is clear that females also develop health problems with obesity, the fact that there was such a difference in the vascularization in male and female fat may mean it would be more effective to have different treatments for males and females.

To contact our editorial team please email us at editorial@cnsmedia.com

Related Articles

Health & Nutrition News

Examining DNA derived from GM foods: Scientists probe how it penetrates the body's cells

22 Jan 2019 --- Toxicologists, including scientists from the Far Eastern Federal University (FEFU), studying the potential risks of genetically modified (GM) products have published a review on the fate of the DNA derived from GM food and how it can survive during digestion and penetrate into the cells of the body. One of the key findings is that the micro-ribonucleic acid – one of the main molecules in cells of living organisms – of GM foods that were treated with insecticides and antiviral sprays can affect genetic processes in the bodies of those who consume it.

Health & Nutrition News

Microbiome medicine: “Unlocking” the secrets behind fecal transplant “super donors”

22 Jan 2019 --- Fecal transplants could be used to treat intestinal disorders such as inflammatory bowel disease, and perhaps even help prevent Alzheimer's and cancer, if the secrets of the gut-rejuvenating properties of “super donors” could be unlocked, say Australian researchers. The researchers reviewed fecal transplantation trials for clues to the origin of the “super-donor” phenomenon, yet concluded that further research is needed to uncover the role of  external factors, such as diet and naturally occurring gut diversity.

Health & Nutrition News

Sustainable diets? Mixed responses to landmark EAT Lancet dietary overhaul recommendations

21 Jan 2019 --- Industry experts and academics have aired mixed responses to last week’s landmark EAT Lancet study, which calls for an overhaul of global everyday diets to safeguard global health and avoid damage to the planet. The significant recommendations include amendments to food production and reductions in food waste. Although many have welcomed the study’s goals and scientific approach, questions have been posed as to the viability of the far stretching policy changes it proposes, as well as the utility of one set of dietary recommendations deemed to be suitable for everyone.

Health & Nutrition News

Genes affect where our bodies store fat, Swedish study finds

21 Jan 2019 --- Whether your body stores fat around the trunk or in other bodily parts is highly influenced by genetic factors and this effect is more predominant in women than in men. This is according to a recent study from Uppsala University, published in Nature Communications, which measured how fat was distributed in nearly 360,000 voluntary participants.

Health & Nutrition News

Microbiome analysis company Bio-Me inks biomarker deal to boost major Norwegian health study

21 Jan 2019 --- Bio-Me, a start-up specializing in rapid gut microbiome analysis, has entered into an agreement with an unnamed “top” consumer healthcare company associated with the large-scale Nord-Trøndelag Health Study (HUNT). The HUNT 4 study is governed by the Norwegian University of Science and Technology (NTNU) and is reportedly one of the most extensive health studies ever performed. The partnership will see Bio-Me using its Precision Microbiome Profiling (PMP) platform and the HUNT BioBank to identify gut microbiome biomarkers for specific health conditions.

More Articles
URL : http://www.nutritioninsight.com:80/news/females-healthier-fat-protects-them-from-obesity-related-health-issues-mice-study-finds.html