DolCas Biotech announces Curcugen’s 39-fold enhanced bioavailability amid new scientific support

14 Jul 2021 --- DolCas Biotech’s latest pharmacokinetic data reveals its natural native curcumin extract has a 39-fold enhanced bioavailability capability compared to conventional curcuminoids.

The 17-subject randomized, crossover study published in Medicine evaluated the dispersible Curcugen, a 98.5 percent native turmeric (50 percent curcuminoid concentrate) formulation, against conventionally extracted C-95 (a 95 percent curcuminoid extract) to determine the degree of enhanced absorption by the patented brand.

“In understanding the nuances of the curcumin market, we were aware that investigations measuring curcuminoids absorption in the plasma were incomplete,” Dr. Shavon Jackson-Michel, the director of medical and scientific affairs at Dolcas Biotech, tells NutritionInsight.

“To establish a baseline to compare with other brands commercially and to comprehensively evaluate Curcugen’s formulation benefits, we sought a study design that was inclusive of all of these parameters,” she adds.

Absorption explained
These latest findings build on prior investigations, which found that enhanced free curcumin is directly linked to the compound’s ability to bypass the resistance that unformulated curcuminoids encounter when entering the bloodstream and target tissues.

Free curcumin analysis is a direct measurement of the proportion of curcumin ingested that is absorbed across the intestinal barrier and found intact in the plasma.Curcugen benefits gut health, mood balance, exercise efficiency and inflammation.

“There are bioavailability-enhanced curcumin extracts that contain synthetic bio-enhancers that may be regulated and acceptable in the pharma industry but not received as well in the natural foods space,” Jackson-Michel explains.

“There are a greater majority of curcuminoid extracts that contain natural but non-native bio-enhancers which often contribute to more than half of the formulations’ composition,” she says.

“Curcugen’s offering of a 98.5 percent turmeric native composition is showing the dual benefit of having real fidelity to the turmeric rhizome while simultaneously being bioavailable and effective at moderate doses,” she adds.

Natural curcumin extract
Curcugen (the 98.5 percent turmeric-based curcuminoids formula) takes a more natural method to enhance the absorption of curcuminoids.

In concentrating curcuminoids to a 50 percent standard, Curcugen co-extracts turmeric-native resins that are polar and offers the patented “Self-D” bioenhancer-like benefits that facilitate dispersibility.

Curcugen, with its 98.5 percent turmeric-derived base, also prioritizes the presence of other turmeric natives, like polysaccharides and essential oils.

Through enhancement of the brand’s dispersion characteristics, these contribute additional value to both bioavailability and bioactivity.

“We believe there will be many benefits attributed to our natural curcumin extract, including safety benefits as well as efficacy benefits. We have already shown clinical benefits in gut health, as well as mood-related benefits associated with improved gut health,” Jackson-Michel states.Natural native curcumin extract has a 39-fold enhanced bioavailability capability.

“Curcugen’s natural curcuminoids profile paralleling the native ratio of curcumin, DMC (demethoxycurcumin) and BDMC (bisdemethoxycurcumin) in turmeric root has also proven to have a high safety profile, both in acute and chronic, repeat dose usage,” she notes.

Curcumin ingredient on the rise
Curcugen was previously found to reduce self-reported gastrointestinal symptoms like reflux, abdominal pain, indigestion, diarrhea, and constipation.

To add to this, curcumin’s anti-inflammatory pathway may boost both mood and digestive health through the gut-brain axis, according to prior DolCas research.

Meanwhile, a new animal study in India shows that Akay Natural Ingredients’ patented curcumin ingredient can cross the blood-brain barrier and locate which parts of the brain free-form curcuminoids reach.

Moreover, spiceuticals from curcumin, ginger and frankincense are positioned against inflammation.

“We have shown health benefits associated with exercise-induced inflammation and joint health using Curcugen,” Dr. Jackson-Michel explains.

By Nicole Kerr