Study: How “good bacteria” promote gut health by warding off inflammation

09 Jul 2018 --- It is well known that “good bacteria” work with our immune system to keep us healthy and new research, published in Immunity, has identified mechanisms that can help explain why. Researchers found a cellular mechanism by which good bacteria can help the gut stay healthy and protect it from inflammatory bowel diseases. When microbiota, or good bacteria, interact with both the epithelial cells lining the gut and cells of the immune system to ward off disease, the immune responses can be balanced, thereby protecting it from unwanted inflammation.

“Here we defined a role for the microbiota in modulating the immune response in a way that reduces inflammation and limits the damage it can do to the gut,” says corresponding author Dr. Gretchen Diehl, Assistant Professor of Molecular Virology and Microbiology and Co-Director of the Biology of Inflammation Center.

“A significant body of work currently indicates that the microbiota shapes the immune system and helps it to do its job. Disease-causing microbes, such as Salmonella, evoke a strong inflammatory immune response that is directed at eliminating the microbe. But an inflammatory immune response, especially in the intestine, can be damaging to the healthy tissue,” she adds.

Inflammation and immune response
The researchers explain that for an effective immune response, immune cells called antigen-presenting cells direct other immune cells, called T cells, to mount an appropriate inflammatory response to fight microbial invaders. They also direct anti-inflammatory T cells, also known as regulatory T cells, to limit inflammatory immune responses against things like the food we eat and to turn off inflammatory immune responses.

The microbiota help “tune down” the inflammatory response by instructing the antigen-presenting cells to secrete the cytokine IL-10, an important anti-inflammatory molecule. IL-10 dampens inflammatory T cell responses and promotes regulatory T cell responses that keep the balance.

“The result is a balanced response that still can fight off infection like Salmonella, but that is regulated to prevent damage to the healthy intestinal tissue,” Diehl says. “We wanted to know how the microbiota could induce this kind of responses.”

“We found that when we gave the laboratory animals antibiotics, the antigen-presenting cells did not make IL-10. When we put back bacteria in the animals' guts, only bacteria that could attach to the intestinal epithelium triggered IL-10 production by antigen-presenting cells and reduced the inflammatory response,” Diehl says. “It's somewhat counterintuitive because microbes that can attach to the intestinal epithelium are thought of as pathogens that can potentially cause disease. But in this case we found that the attachment of bacteria to the epithelium was not causing disease; on the contrary, it was necessary to promote a balanced regulation of the T cell responses and helped protect the gut.”

The researchers indicate that their study is barely scratching the surface, and they are actively looking for other mechanisms by which microbes can promote a well-balanced intestinal environment.

“A take-home message for us is that a healthy microbiota is necessary to allow for a balanced response to not only protect us from infection but also to limit potential tissue damage as the immune system attempts to eliminate pathogens,” Diehl concludes.

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