Faulty Fat Sensor Implicated in Obesity and Liver Disease

20 Feb 2012 --- The researchers analysed the gene for GPR120 in 6,942 obese people and 7,654 controls to test whether differences in the code that carries instructions for making the protein contribute to obesity in humans.

Feb 20 2012 --- Defects in a protein that functions as a dietary fat sensor may be a cause of obesity and liver disease, according to a study published in the journal Nature, led by researchers at Imperial College London. The findings highlight a promising target for new drugs to treat obesity and metabolic disorders.

The protein GPR120 is found on the surface of cells in the gut, liver and fat tissue and allows cells to detect and respond to unsaturated fatty acids from the diet, especially the omega-3 fatty acids which are believed to have a beneficial impact on health. Scientists found that mice deficient in GPR120 were more prone to developing obesity and liver disease when fed a high-fat diet. They also found that people with a certain mutation in the gene encoding GPR120, which stops the protein from responding to omega-3 fatty acids, were significantly more likely to be obese.

In the gut, when unsaturated fatty acids from food bind to GPR120, this stimulates the release of hormones that suppress appetite and stimulate the pancreas to secrete insulin. When fat cells sense high levels of fat in the blood through GPR120, it stimulates them to divide to produce more fat cells to store all the fat, reducing the risk of fatty liver and furring of the arteries. This mechanism could be an important pathway for bringing about some of the healthy effects of omega-3s.

When they were fed on a high-fat diet, mice that lacked GPR120 not only became obese but also had fatty livers, lower numbers of fat cells, and poor control of blood glucose. The researchers believe that mice that are deficient in GPR120 have difficulty storing excess fat in fat tissue. Instead, their bodies store fat in areas where it can cause health problems, like the liver, the muscles and in the walls of arteries. In humans, this pattern of obesity is associated with type 2 diabetes and heart disease.

The study involved scientists in the UK, France and Japan. It was led by Professor Philippe Froguel, from the School of Public Health at Imperial College London.

"Being overweight is not always unhealthy if you can make more fat cells to store fat," said Professor Froguel. "Some people seem to be unable to do this, and instead they deposit fat around their internal organs, which is very unhealthy. Our study suggests that in both mice and humans, defects in GPR120 combined with a high-fat diet greatly increase the risk of this unhealthy pattern of obesity. We think GPR120 could be a useful target for new drugs to treat obesity and liver diseases."

The researchers analysed the gene for GPR120 in 6,942 obese people and 7,654 controls to test whether differences in the code that carries instructions for making the protein contribute to obesity in humans. They found that one mutation that renders the protein dysfunctional increases a person's risk of obesity by 60 per cent. The researchers think this mutation mimics the effect of a bad diet lacking in unsaturated omega-3 fat.

Related Articles

Health & Nutrition News

Daily Handful of Walnuts Linked to Improvements in Some Health Risk Factors

26 Nov 2015 --- Eating a daily handful of walnuts is linked to better overall diet quality and an improvement in certain risk factors among people at high risk of diabetes, finds research published in the online journal BMJ Open Diabetes Research & Care.

Health & Nutrition News

High-Fat Diet Prompts Brain Connection Breakdown

26 Nov 2015 --- When a high-fat diet causes us to become obese, it also appears to prompt normally bustling immune cells in our brain to become sedentary and start consuming the connections between our neurons, scientists say.

Health & Nutrition News

Stored Fat Fights Body's Attempts to Lose Weight

26 Nov 2015 --- The fatter we are, the more our body appears to produce a protein that inhibits our ability to burn fat, suggests new research published in the journal Nature Communication. The findings may have implications for the treatment of obesity and other metabolic diseases.

Food Ingredients News

Food Industry Can Help Lower Cardiovascular Diseases by Adding Seaweed to Products

25 Nov 2015 --- Adding seaweed to processed foods such as frozen pizzas, hot dogs and dried pasta will reduce cardiovascular diseases, concludes a new scientific article. One suggestion is to replace 5% of the flour in pizza dough with dried and granulated seaweed.

More Articles
URL : http://www.nutritioninsight.com:80/news/Faulty-Fat-Sensor-Implicated-in-Obesity-and-Liver-Disease.html