Uncovered: Why Drinking Red Wine May Reduce Risk of Heart Disease
07 Apr 2016 --- The gut may be the reason why drinking red wine can reduce risk of heart disease, according to new research.
The compound resveratrol found in red wine contains antioxidant properties which may prevent the build-up of plaque in arteries that leads to heart disease
A discovery by Chinese scientists has uncovered this mechanism, and suggests that targeting microbiota in the gut may be the way to reduce heart disease.
Cardiovascular diseases are the leading cause of death in industrialized societies and are a growing concern in developing countries.
Furring of arteries, or atherosclerosis, could be a direct result of a chemical TMAO (trimethylamine-N-oxide) in the gut, which red wine's resveratrol inhibits.
Dr Man-tian Mi, a researcher at the Research Centre for Nutrition and Food Safety in China, said: "Our results offer new insights into the mechanisms responsible for resveratrol's anti-atherosclerosis effects and indicate that gut microbiota may become an interesting target for pharmacological or dietary interventions to decrease the risk of developing cardiovascular diseases."
Dr Mi and his team conducted a number of experiments using mice to determine whether the protective effect of resveratrol against atherosclerosis was related to changes in gut microbiome.
They found that resveratrol reduces levels of TMAO a known contributor to the development of atherosclerosis.
The study, published in the journal mBio from the American Society for Microbiology, also shows that resveratrol prevents TMA production by gut bacteria, TMA is necessary for the production of TMAO.
Now the researchers are attempting to further define the role of resveratrol in cardiovascular disease to replicate their findings in humans.
Dr Mi added: "In our current study we found that resveratrol can model the gut microbiota including increasing the Bacteroidetes-to-Firmicutes ratios, significantly inhibiting the growth of Prevotella and increasing the relative abundance of Bacteroides, Lactobacillus, Bifidobacterium and Akkermansia in mice.”
"Resveratrol reduces TMAO levels by inhibiting the gut microbial TMA formation via remodeling gut microbiota."
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