UK researchers call for fortification of flour with folic acid as upper limit for intake of folate is “invalid”

31 Jan 2018 --- There is no need for an upper limit of folate intake as the maximum suggested intake of folate (1 mg/day) is based on a “flawed” analysis, according to a study by Queen Mary University of London and the School of Advanced Study, University of London. The findings support recent calls for the UK Department of Health to approve the fortification of flour with folic acid, to protect babies from having neural tube defects.

Anencephaly and spina bifida (collectively referred to as neural tube defects) are relatively common but serious birth defects, affecting 1 in every 500-1,000 pregnancies. In 1991, a Medical Research Council randomized trial showed that increasing folic acid intake immediately before and early in pregnancy prevented most cases of neural tube defects.

As a result, 81 countries, including the US since 1998, have introduced mandatory folic acid fortification of cereals, which has been found to reduce the prevalence of neural tube defects, without any evidence of harm. In countries that have introduced fortification, the number of neural tube defects has decreased by up to a half.

Despite successive recommendations, the UK has not introduced mandatory fortification. One reason given is that this might lead to more people having a folate intake above an "upper limit" suggested by the US Institute of Medicine (IOM). The new research, published in Public Health Reviews, says that the IOM analysis was "flawed" and there is no need for an upper limit.

The IOM analyzed the results of studies, mainly conducted half a century ago, on individuals with B12 deficiency who had been wrongly treated with folic acid, and claimed that neurological damage tended to occur more frequently in patients treated with higher doses of folic acid. The IOM concluded that treating individuals with vitamin B12 deficiency with higher doses of folic acid might lead to an increased risk of neurological damage.

The new re-analysis of the data finds no relationship between dose of folic acid and the development of neurological damage. The neurological damage was not caused by folic acid - it arose by not treating B12 deficiency with vitamin B12. As a result there is no need for a folate upper limit (just as there is no upper limit for other B vitamins such as B1, B2, B5 or B12).

"Failing to fortify flour with folic acid to prevent neural tube defects is like having a polio vaccine and not using it. Every day in the UK, on average two women have a termination of pregnancy because of a neural tube defect and every week two women give birth to an affected child," says lead author Professor Sir Nicholas Wald from the Wolfson Institute of Preventive Medicine at Queen Mary, who also led the original 1991 randomized trial.

Women who could become pregnant are advised to start taking a daily folic acid supplement, but most do not do so, emphasizing the need for fortification. Even with fortification, women should still be advised to take folic acid supplements to achieve a greater level of protection than that afforded by fortification alone. The importance of fortification is that it provides a protective population safety net. In the UK, white flour is already fortified with iron, calcium and other B vitamins (niacin and thiamin).

Co-author Professor Joan Morris from the Wolfson Institute of Preventive Medicine at Queen Mary said: "From 1998, when the United States introduced mandatory folic acid fortification, to 2017, an estimated 3,000 neural tube defects could have been prevented if the UK had adopted the same level of fortification as in the US. It's a completely avoidable tragedy."