TSI Group’s enfinity paraxanthine linked to improved cognitive performance and weight loss

30 May 2024 --- Two recently published research papers investigate the effects of enfinity paraxanthine, a pure and patent-pending metabolite of caffeine, on mental stamina. One reveals that paraxanthine provides greater improvement in cognitive function than caffeine after a 10 km run, and the other linked the ingredient to increased energy expenditure — the number of calories burned without additional activity — that may facilitate weight loss.

“Paraxanthine alone significantly improved cognitive performance. In contrast, caffeine alone increased the amount of errors to a shocking extent,” explains Dr. Ralf Jäger, enfinity energy partner, researcher and co-author of both papers. “The results for those who received a combination of paraxanthine and caffeine were only slightly better than the caffeine group. They didn’t get the full benefits of paraxanthine.” 

Commenting on the second study related to caloric expenditure, he adds: “While it was natural for all participants to become progressively hungrier, with paraxanthine, we saw a reduction in increased hunger over time when compared with the control group.” 

Responding to the findings, TSI Group president Larry Kolb underscores: “We are in the midst of a revolution within the caffeine space. As the exclusive global distributor for enfinity, TSI is excited to provide consumers with cleaner options that perform as well or better than what they may currently be using.”

Improved cognition
The double-blind, randomized trial study published in the Journal of the International Society of Sports Nutrition considered and compared the effects of paraxanthine and caffeine following mental exhaustion triggered by exercise.

Paraxanthine alone was shown to more significantly improve cognitive performance than coffee.Jäger explains: “We wanted to evaluate the subjects’ cognitive performance, comparing enfinity with caffeine, and look at what happens if you combine enfinity with caffeine.” 

The participants, 12 trained runners, were randomly assigned 400 mg of a placebo, 200 mg of a placebo and 200 mg of caffeine or 200 mg of a placebo and 200 mg of paraxanthine. The research team determined that after completing a 10 km run, the participants given paraxanthine experienced improved mental stamina and were less likely to make cognitive errors.

This suggested that paraxanthine may be more effective than caffeine in enhancing mental performance under stress. 

“We get asked a lot about combining paraxanthine with caffeine. In highly stressful or challenging cognitive situations, paraxanthine allows you to switch between tasks more efficiently and faster without increasing the number of errors, whereas caffeine does not show this beneficial effect. If you’re looking for these specific benefits, use paraxanthine on its own,” asserts Jäger.

Hunger and appetite
In a second randomized, double-blind, placebo-controlled study published in the Journal of Dietary Supplements, the research team looked at enfinity’s thermogenic effects at 100, 200 and 300 mg doses. 

The researchers applied a gold standard caffeine study model, using energy expenditure as the primary measurement.

“We saw a significant increase in resting energy expenditure with paraxanthine supplementation at 200 mg, an additional 100 kilocalories in three hours. At 100 mg, there was a slight increase, but it wasn’t statistically significant. A 300 mg dose didn’t add additional benefit,” comments Jäger. 

The metabolite of caffeine may reduce hunger cravings.He notes that subjects fasted before the test and another three hours after supplementation, noting a limited increase in hunger among the participants receiving paraxanthine in comparison to the control group.

Partner Shawn Wells, also co-author of both papers, comments: “There are very few thermogenic ingredients. That’s why the caffeine model is the gold standard. We are excited that enfinity paraxanthine now joins caffeine, green tea extract, capsaicin and a few others that are moving the needle.” 

“The enfinity paraxanthine stands out not just for its effectiveness but for its safety and the absence of common caffeine-induced side effects. It offers a smoother, cleaner stimulation, making it suitable for anyone seeking sustained mental and physical performance.”

Wells further explains that close to 70% of caffeine is metabolized as paraxanthine, as it is caffeine’s most efficacious compound. “It goes straight to work, bypassing the side-effect ridden ‘middlemen’ (theophylline, theobromine and their metabolites), as well as the problematic caffeine itself.”

TSI Group’s enfinity paraxanthine has also been touted for its benefits to healthy aging. 

By Milana Nikolova