Study: Amazonian fruit prevents obesity in overfed mice

04 Sep 2018 --- An extract of camu camu – a fruit native to the Amazon – prevents obesity in mice fed a diet rich in sugar and fat, researchers at Université Laval and the Quebec Heart and Lung Institute Research Centre have found. The discovery, published in Gut, suggests that camu camu phytochemicals could play a leading role in the fight against obesity and metabolic disease.

The chemical composition of camu camu is unique in that it contains 20 to 30 times more vitamin C than kiwis and five times more polyphenols than blackberries. 

“We demonstrated the beneficial health effects of polyphenol-rich berries in previous studies,” says André Marette, Professor at Université Laval's Faculty of Medicine and principal investigator for the study. “That's what gave us the idea to test the effects of camu camu on obesity and metabolic disease.”

The researchers fed two groups of mice a diet rich in sugar and fat for eight weeks. Half the mice were given camu camu extract each day. At the end of the experiment, weight gain in camu camu-treated mice was 50 percent lower than that observed in control mice and was similar to the weight gain of mice consuming a low-sugar, low-fat diet. The researchers believe the anti-obesity effect of camu camu could be explained by an increase in resting metabolism in the mice that received the extract.

The researchers also found that camu camu improved glucose tolerance and insulin sensitivity and reduced the concentration of blood endotoxins and metabolic inflammation. “All these changes were accompanied by a reshaping of the intestinal microbiota, including a blooming of A. muciniphila and a significant reduction in Lactobacillus bacteria,” says Dr. Marette. 

Transplantation of intestinal microbiota from the camu camu group to germ-free mice lacking an intestinal microbiota temporarily reproduced similar metabolic effects. “Camu camu thus exerts its positive metabolic effects at least in part through the modulation of the gut microbiota,” concludes the researcher.

André Marette now wants to examine whether camu camu produces the same metabolic effects in humans. The toxicity of the fruit extract should not pose a problem since it is already commercialized to combat fatigue and stress and stimulate the immune system.