Studies shed light on negative effects of excess weight on arthritis patients

ca52ee7e-6e9d-4c75-82d8-64485d4e4641articleimage.jpg

04 Dec 2017 --- New research provides insights on the potential negative effects of overweight and obesity on the health of individuals with rheumatoid arthritis (RA). A study published in Arthritis Care & Research examines how overweight and obesity may negatively affect the likelihood of achieving remission in early RA. A separate study in Arthritis & Rheumatology focuses on weight change in early RA and patients’ subsequent risk of early death.

Research has suggested that weight may influence the effectiveness of RA therapies. In an Arthritis Care & Research study, Susan Goodman, M.D., of the Hospital for Special Surgery and Weill Cornell Medical School, and her colleagues investigated the potential impact of weight on the likelihood that patients would achieve remission in the early years after an RA diagnosis.

Determining weight’s effect on outcomes
The team examined data from the Canadian Early Arthritis Cohort, a multicenter observational trial of patients with early RA who were treated by rheumatologists using guideline-based care.

“Our study looks at people with recently diagnosed, early RA, who should have the best outcomes and best responses to treatment, and sees how many are either overweight or obese, and then determines if those who are overweight or obese have worse outcomes than those with healthy weight,” says Dr. Goodman.

Of 982 patients, 32 percent had a healthy BMI, 35 percent were overweight and 33 percent were obese. Within three years, 36 percent of patients experienced sustained remission. Compared with patients with a healthy BMI, those who were overweight were 25 percent less likely to experience sustained remission, and those who were obese were 47 percent less likely to do so, despite receiving similar treatments.

The research represents the largest study demonstrating the negative impact of excess weight on the RA disease activity and supports a call to action to better identify and address this risk in patients.

“These findings have important implications for clinical care since rates of overweight and obesity continue to rise,” says Dr. Goodman. “Our findings highlight the high proportion of newly diagnosed RA patients who are overweight or obese and who may have disease that is harder to treat. For people with RA who haven’t had an adequate response to treatment, this may be another factor to consider.”

“Obesity paradox”
In other studies, obesity has been associated with a decreased risk of early death; however, follow-up studies suggest that this “obesity paradox” may be explained by unintentional weight loss in the few years preceding death, rather than a truly protective effect of obesity. According to this explanation, patients with longstanding RA who reached normal or underweight BMI have higher observed mortality and are relatively less healthy than RA patients who maintained obesity or overweight.

To investigate the issue, Jeffrey Sparks, M.D., of Brigham and Women’s Hospital and Harvard Medical School, and his colleagues evaluated the effect of weight change in the early stages of RA on subsequent mortality risk. Their Arthritis & Rheumatology study included 902 women diagnosed with RA in the Nurses’ Health Study and 7,884 matched women without RA.

Women with RA had higher mortality rates than women without RA. Among women with RA, 41 percent died during an average follow-up of 17.0 years after the early RA period; among women without RA, 29.2 percent died during an average follow-up of 18.4 years. In both groups, women who had severe weight loss (>30 pounds) had the highest mortality rates after the early RA period. Weight gain in the early RA period was not associated with mortality for either group.

“Our study is the first to focus on weight change around RA diagnosis and risk of death, rather than weight change in patients who had RA for many years, as in previous studies,” says Dr. Sparks. “Our findings provide evidence that the results of earlier studies – that patients who had normal weights were at higher risk of death – may have been related to unintended weight loss as opposed to a protective effect of being overweight or obese.”

“Our results demonstrate that these prior findings were less likely to be directly related to RA and were likely a phenomenon of frailty and aging of the general population,” Dr. Sparks adds.

To contact our editorial team please email us at editorial@cnsmedia.com

Related Articles

Health & Nutrition News

Family awareness highlighted during World Diabetes Day

14 Nov 2018 --- Four in five parents have trouble recognizing the warning signs of diabetes, according to research by the International Diabetes Federation (IDF). To mark this year’s World Diabetes Day, IDF is seeking to raise awareness of the effect diabetes has on the family, with a particular focus on prevention and management of the disease. 

Food Ingredients News

Diabetes and cardiovascular disease top the list of health fears for older men, Lycored reveals

13 Nov 2018 --- Diabetes and cardiovascular disease are the most common health concerns for older men in the west, a new survey by wellness company Lycored has revealed. The research also indicates that  US men are more worried about heart disease than they are about cancer.

Health & Nutrition News

World’s first celiac vaccine enters international Phase 2 trial

07 Nov 2018 --- The world's first vaccine for people who have celiac disease is to be rolled out in an international trial. If successful, the vaccine, Nexvax2, would be the first medicine of its kind for people with the disease. Currently, following a gluten-free diet is the only treatment, but even the most diligent patients can suffer the adverse effects of accidental exposure. Therefore, the results of the vaccine’s trial may be eagerly awaited by those avoiding gluten due to their celiac condition.

Health & Nutrition News

Go nuts: Nuts linked to weight control

06 Nov 2018 --- One serving of nuts a day may help keep weight gain at bay, according to two different studies commissioned by the American Heart Association. One study focuses on Brazil nuts and how they improve satiety and prevent insulin levels from spiking. The other deals with the consumption of nuts and peanuts and how they may help manage weight gain in both men and women. 

Health & Nutrition News

Childhood use of antibiotics and antacids linked to heightened obesity risk

02 Nov 2018 --- The gut microbiome has been linked to various aspects of human health, including obesity. Researchers at Walter Reed National Military Medical Center have now found that certain drugs, such as antibiotics, acid suppressants-histamine 2 receptor antagonists (H2RA) and proton pump inhibitors (PPIs), can alter the type and volume of bacteria in the gut. These medications, which are often over-prescribed in children, may have significant negative effects on health that were previously underappreciated, the researchers note.

More Articles
URL : http://www.nutritioninsight.com:80/news/studies-shed-light-on-negative-effects-of-excess-weight-on-arthritis-patients.html