18 Oct 2023 --- Researchers at the US National Institutes of Health suggest that reducing overall calorie intake may benefit muscle health. Over the course of two years, participants who restricted their calories by 12% without depriving the body of essential vitamins and minerals activated most biological pathways essential to healthy aging. Although the researchers found that sustained calorie restriction did induce minor leg lean mass losses, they revealed that muscle strength remained unchanged. Additionally, it improved skeletal muscle quality and impacted gene expression and splicing profiles of biological pathways affected by reducing calorie intake.
