Scientific Researches Confirm Peptan Hydrolyzed Collagen Benefits on Bone Health

Researchers conducted in vitro studies, and highlighted that Peptan in bone cell culture induced a better differentiation of osteoblasts. Those positive results have then been confirmed in vivo on ovariectomized mice, used to simulate a postmenopausal osteoporosis, which leads to a lower bone mineral density (BMD).

16 Dec 2009 --- In response to consumer concerns regarding long-term bone health, Rousselot has carried out, for several years now, many studies to demonstrate that an oral intake of Peptan may have a positive impact on osteoporosis. Studies conducted at INRA-Agroparistech Laboratory under Pr. Daniel Tomé's supervision and published in November 2009, in the Official Journal of the International Bone and Mineral Society "Bone", reveal new benefits for Peptan in osteoporosis prevention.

Bone is a living dynamic metabolic system that relies on a maintained balance between bone formation and bone resorption. Cells called osteoblasts make bone while cells called osteoclasts resorb it. An imbalance may lead to osteoporosis, a condition where the density and quality of bone is reduced.

Researchers conducted in vitro studies, and highlighted that Peptan in bone cell culture induced a better differentiation of osteoblasts. Those positive results have then been confirmed in vivo on ovariectomized mice, used to simulate a postmenopausal osteoporosis, which leads to a lower bone mineral density (BMD).

Animals were divided into three groups: a control group (non ovariectomized), a group of ovariectomized mice, both fed with a normal diet and a group of ovariectomized mice that received a diet containing Peptan. After 12 weeks, the BMD of the group fed with Peptan is not significantly different from the BMD of control group. On the contrary the BMD of ovariectomized mice not fed with Peptan is lower.

Confirmation of Peptan benefits on bone health has been obtained by the measures of Carboxy Terminal Telopeptide (CTX), a usual marker of bone resorption. CTX is significantly lower in mice fed with Peptan indicating that bone resorption is reduced.

Researchers conclude that Peptan may restore bone density in simulated post-menopausal osteoporosis by stimulating osteoblast growth and differentiation. This demonstrates the interest of Peptan as a bioactive ingredient to help preventing bone loss during aging.