Resveratrol Could Suppress Pathogen that Causes Inflammation
20 Oct 2016 --- Resveratrol, a component of red wine and grapes, may help control inflammation induced by a bacterial pathogen that is linked to upper respiratory tract inflammatory diseases, according to a new study published in Scientific Reports. “It has been shown that resveratrol can suppress inflammation, but how it regulates inflammation still remains largely unknown,” said Jian-Dong Li, a senior author of the study, director of the Institute for Biomedical Sciences at Georgia State, and a Georgia Research Alliance Eminent Scholar. “We found that resveratrol suppresses a major bacterial pathogen causing otitis media and chronic obstructive pulmonary diseases (COPD) by up-regulating or increasing the production of a negative regulator called MyD88 short.” Resveratrol belongs to a group of compounds called polyphenols that are thought to act like antioxidants and protect the body against damage. It has long been considered a therapeutic agent for various diseases, including inflammatory diseases. In the study, resveratrol was effective against inflammation caused by nontypeable Haemophilus influenzae (NTHi), a major respiratory pathogen. This study found for the first time that resveratrol decreases NTHi-induced expression of pro-inflammatory mediators in airway epithelial cells and in the lungs of mice by enhancing MyD88 short, a negative regulator of inflammatory signaling pathways. MyD88 short is considered a “brake pedal protein” because it can tightly control inflammation induced by this respiratory pathogen. It could be a critical target with significant therapeutic potential for suppressing inflammation associated with chronic airway disease. The researchers also found that resveratrol has anti-inflammatory effects after NTHi infection, which demonstrates its therapeutic potential. To contact our editorial team please email us at editorial@cnsmedia.com
Related ArticlesHealth & Nutrition News A green diet revolution? Calls for radical diet and food production intervention to improve health and the planet17 Jan 2019 --- Feeding a growing population of 10 billion people by 2050 with a healthy and environmentally friendly diet will be impossible without dramatically transforming the global population’s eating habits, improving food production and reducing food waste. This is according to a Lancet commission of prominent academics that has put forward a planetary health diet. Health & Nutrition News Fasting may improve health and shield against age-related diseases, study finds17 Jan 2019 --- Fasting intermittently (IF) may reprogram a variety of cellular responses and result in a range of health benefits, according to a US study conducted on mice. Fasting was found to affect circadian clocks in the liver and skeletal muscles, causing them to rewire their metabolism, which may promote health and protect from age-related diseases. The research, published in Cell Reports, opens new pathways of investigation that may lead to the development of nutritional strategies to improve health in humans. Health & Nutrition News Claiming concentration? Red Bull cautioned by UK advertising watchdog for “misleading” health claim17 Jan 2019 --- UK advertising watchdog, the Advertising Standards Authority (ASA), has banned a poster for the energy drink Red Bull for reportedly implying that Red Bull has a beneficial impact on health, in particular, focus and concentration. Suggesting a product aids focus and concentration is a health claim, and therefore must comply with the claims authorized on the EU register. This is According to Regulation (EC) 1924/2006 on nutrition and health claims made on foods. Health claims are defined as those that state, suggest or imply a relationship between a food, or ingredient and health. Packaging & Technology News First time for Europe: Spanish supermarket chain launches Nutri-score labeling16 Jan 2019 --- Spanish supermarket chain Eroski has introduced a handful of own-brand products featuring Nutri-Score labeling. This makes Eroski the first distribution company in Spain to incorporate this “advanced nutrition” labeling. The Nutri-Score system classifies foods into five levels, indicated by colored letters – from “A” in dark green to “E” in dark orange. It is calculated on the basis of the calories, the nutrients which are beneficial for our health – fiber, protein, amount of fruit, vegetables, nuts and pulses – and nutrients whose intake should be reduced – saturated fat, salt and sugar – per 100 grams of the product. Health & Nutrition News Microbiome holds potential for treating milk allergy, mice study finds16 Jan 2019 --- Gut microbes from healthy infant donors transplanted into mice prevented allergic reactions to milk, while gut microbes from infant donors with milk allergies failed to do the same, according to a Chicago University study. Supported by the US National Institutes of Health (NIH) and published in Nature Medicine, the study findings suggest that gut microbes can significantly affect allergic responses to foods. More Articles |
.jpg)
