08 May 2015 --- New research reports further natural solutions for those at heightened risk of coronary artery disease (CAD) – the number one killer in America. A study published in the Journal of International Angiology found that daily supplementation of Pycnogenol (pic-noj-en-all), a standardized natural plant extract from French maritime pine tree bark, may help improve endothelial function for those with borderline hypertension, hyperglycemia, or hyperlipidemia.