Gnosis’s SAMe Superesse Nutritional Yeast Opens New Opportunities and Markets for S-Adenosylmethionine

This is after the grant of the health claim of Gnosis’ Superesse, the enriched natural yeast with S-Adenosylmethionine (SAMe), by The Japanese Ministry of Health, Labour and Welfare (MHLW) for the "Improvement for the joint wrongness".

Recognition of the health claim on joints follows the publication of a placebo-controlled double-blind randomized clinical trial in healthy male and female adults, aged 40 to < 59 years, who had chronic discomfort in the knee joint and that had persisted for at least 3 months at the time of enrollment with no history of OA. (N. Yamanaka, et al. “The effects of SAM-e yeast to improve the discomfort of knee in healthy adults” Jpn Pharmacol Ther vol.43 no. 4 2015).

 

Japan is thought to be the leader in the manufacture and use of "Foods with Health Claims" – the preferred term for dietary supplements and natural nutraceuticals. The health-conscious Japanese have long embraced the benefits from nutraceuticals, and the country ranked third in per capita spend on nutraceuticals in 2014 according to World Health Organization (WHO) data, while others place Japan as the second largest individual consumer of nutraceuticals (behind the US).

 

The effectiveness of SAMe Superesse was evaluated through a symptom scores on a questionnaire, which takes the format of a scale from 0 to 10, or a VAS (visual analogue scale). The questionnaire items used the “Locomotive Syndrome Risk Test”) presented by the Japanese Orthopedic Association as a reference, and the subjective symptoms of the 10 items set were the targets for evaluation.
 
The use of Saccharomyces cerevisiae (the primary yeast used in baking and brewing) is very known because it represents an excellent source of several nutritional compounds such as vitamins and proteins, fruitful for human health. As ‘nutritional yeasts’ it is used in the form of dried and inactive yeasts and may contains also other important substances, as happens in the Superesse product SAMe. These natural components are available in the native structure, and they are biologically active.

 

The product has been designed by Gnosis combining the expertise in biofermentation processes and the knowledge as the leading global manufacturer of SAMe to obtain a new ingredient for the food market.

 

SupereSSe activity derives from the natural content of (S,S) SAM-e stereoisomer contained in the dried cells. This metabolite is present in all living cells and plays a central role in cellular biochemistry centered in one carbon metabolism cycle. SAMe is involved in over 35 methylation reactions related to DNA, proteins, lipids and hormones, impacting cellular function in countless ways, among them, neurotransmitter synthesis and membrane function. (S,S) is the biologically active form of SAMe that produces healthy benefits, supporting joint functions, but also mood and emotional well-being, working as a liver protector as well.

 

Superesse guarantees stable form without addition of stabilizing agents.  It is highly flavorful and simple to administer (direct administration of product in suitable nutraceutical forms especially capsules, tablets and sachets). It can be easy combined with other ingredients and excipients.