The US FDA and National Institutes of Health (NIH) will invest in science to better understand the root causes of diet-related chronic diseases. They aim to implement and advance a comprehensive nutrition research agenda in the Nutrition Regulatory Science Program. This agenda will provide information to inform effective food and nutrition policy and help make US food and diets healthier. The FDA and NIH note that their joint research initiative will be key to fulfilling Health and Human Services Secretary Robert F. Kennedy Jr.’s commitment to “Make America Healthy Again.”