Diabetes Drugs Breakthrough

07/10/05 University of Ulster scientists are developing innovative drugs that could represent important new therapeutic tools to help ease the burden of diabetes worldwide. The news comes as a UN World Health Organisation report identifies diabetes as one of the major health issues facing the world in the 21st century.

The research team at UU have discovered that modified-forms of GIP, a naturally occurring molecule produced by the body, can combat key symptoms of diabetes. This stimulated the formation of a new company to develop production of new anti-diabetic agents. Current statistics report some 150 million diagnosed cases of diabetes worldwide, and that figure is set to double within 20 years, according Dr Neville McClenaghan, a prime mover in the new company Diabetica Limited.“The holy grail of diabetes treatment is safe and effective management of blood glucose.

We believe that novel molecules arising from our platform GIP technology should provide effective new tools to help individuals better control the condition known as Type 2 diabetes,” he said.“That’s really what physicians are looking for at the minute - new drugs that offer improvements or enhancement over current drugs.”Diabetes is a complex metabolic disorder clinically defined by high blood glucose levels resulting from a relative or absolute absence of insulin-production coupled with defective insulin action in body tissues.

The latter is a defining characteristic of the ‘metabolic syndrome’ and is an important link between Type 2 diabetes and other conditions including obesity, heart disease and stroke.In diabetes there is a breakdown in the person’s ability to regulate blood-glucose levels, and thus pharmacological treatments are required to bring the blood glucose levels back down to safe levels. The main pharmacological approaches to the treatment of diabetes are focussed on replacing insulin by injection or the use of drugs, which either increase circulating insulin or enhance its action on insulin-sensitive tissues.

“Diabetes and the related conditions, metabolic syndrome and obesity, are reaching epidemic proportions and thus are major healthcare challenges. This clearly prompts the development of new and innovative approaches for effective management and treatment of this complex disease” said Dr McClenaghan.Years of research by the team at UU have culminated in two distinct therapeutic products developed from the gut peptide, GIP, which is released into the blood following eating.

Preclinical studies have revealed that both therapeutic products exhibit potent glucose-lowering actions mediated by either increasing circulating insulin or enhancing insulin action.

“We have discovered that strategic bio-engineering of the GIP molecule can generate stable long-acting forms with two principal modes of anti-diabetic action and have patent-protected the technology,” he said.

“Diabetica’s therapeutic GIP products have generated a lot of interest. GIP-based therapies are exciting new approaches which offer considerable advantages over existing and emerging diabetes/obesity therapies, which suffer from shortcomings such as poor efficacy, difficult dosing regimens and adverse side effects.

This is a very exciting time for Diabetica as our two novel GIP drugs - Incretide and Metalog - could provide a major advance in the effective management of diabetes, metabolic syndrome and obesity.”The co-founders of Diabetica Limited - Professor Peter Flatt, Professor Finbarr O’Harte and Dr Neville McClenaghan - established the Coleraine-based biotechnology company last year as a first step to achieving a sound commercial footing for product development.In June, the University’s technology transfer arm, UUTech Limited and Seroba BioVentures Limited, a life sciences venture capital fund, announced that they would provide funding for Diabetica’s pre-clinical testing programmes.

Dr McClenaghan said: “We now wish to take our GIP drugs through formal clinical evaluation. Clinical trials are a vital step along the way to full approval and prescribed use of any drug. Diabetica’s GIP drugs, Incretide and Metalog, are two distinctly different products addressing the major unmet need for “smart therapeutics” whose actions are regulated by circulating levels of blood glucose. Thus, we anticipate that Incretide and Metalog will offer the individual immediate advantages associated with better control of blood glucose levels and reducing the likelihood of development of complications associated with long-term hyperglycaemia.

”The increasing global incidence of diabetes has led to major investments by the bio-pharmaceutical industry to develop and acquire therapeutic, drug delivery and diagnostic solutions for diabetes and obesity, creating significant opportunities for Diabetica’s novel therapeutics as the anti-diabetic and anti-obesity drugs of tomorrow.

Brian O'Connor, Chairman of UUTech said: “UUTech is pleased at the progress made so far and will work to ensure that Diabetica has the best possible chance of success during the development phase of this exciting science over the next several years."“We are delighted with the validation this funding gives to our technology,” said Matt O’Driscoll, Chief Executive Officer of Diabetica. “This is the first stage in a fundraising and corporate partnering campaign over the next 12 months designed to push the development of our lead GIP molecules into the clinic.”