Clinical research validates TocoGaia for healthy aging, antioxidant defense and genomic stability

A human clinical study has confirmed that a tocotrienol-enriched functional beverage, containing PhytoGaia’s TocoGaia, delivers “clinically meaningful anti-aging improvements.” These benefits include “enhanced psychological quality of life, stronger antioxidant defenses, and better maintained telomerase activity, a key marker of genomic stability in healthy aging adults.”

The study spanned six months and involved 67 healthy participants between the ages of 50 and 70. Researchers at the National University of Malaysia conducted the trial.

The key clinical findings from the study showed clinically meaningful improvement in psychological well-being, such as better mood and emotional resilience, when participants consumed the tocotrienol-enriched beverage.

“This is one of the most comprehensive human trials to date showing that tocotrienols (TocoGaia) can positively modulate several key hallmarks of aging, from reducing inflammation and oxidative stress to enhancing genomic protection,” says Dr. Ariati Aris, scientific affairs specialist at PhytoGaia.

“What’s truly encouraging is that these benefits were seen within just six months of supplementation, with no reported side effects. These findings add robust support to the growing scientific evidence positioning tocotrienols (TocoGaia) as a safe and effective nutraceutical for healthy aging.”

Antioxidant and cellular aging benefits

Additionally, TocoGaia preserves the antioxidant enzyme activity of superoxide dismutase and catalase, which are key in the body’s antioxidant defense to protect against oxidative stress.

The study also reported a boost in telomerase activity in the TocoGaia group. Telomerase — an enzyme critical for maintaining telomere length — was significantly elevated in this group, suggesting enhanced genomic stability and a potential slowing down of cellular aging.

The study finds TocoGaia reduces inflammation and oxidative DNA damage.Furthermore, the research indicated reduced inflammation and oxidative DNA damage, with the supplemented group showing reductions in key inflammatory markers such as TNF-α, as well as other cytokines including IL-6 and TGF-β, along with lower levels of 8-OHdG, a biomarker of oxidative DNA damage. This highlights tocotrienol’s role in modulating inflammation and promoting cellular integrity.

Importantly, the study highlighted an excellent safety profile as “no adverse effects were reported.” Clinical markers such as cortisol, insulin, liver enzymes, and lipid levels remained stable within normal ranges throughout the study.

“This study comes at a pivotal time when brands and consumers alike are demanding natural, effective, and, above all, safe solutions for healthy aging,” comments Bryan See, VP of PhytoGaia.

Synergies with squalene

The study is titled “A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Effects of Tocotrienol-Rich Vitamin E on Quality of Life, Antioxidant Status, and Genomic Stability in Older Adults” and was recently published in Nutrients.

PhytoGaia also offers STGaia, a novel synergistic formulation of plant squalene and tocotrienols/tocopherol developed specifically to support healthy aging across both internal and external dimensions, including skin nutrition, mitochondrial health, and hair vitality.

While TocoGaia claims to preserve antioxidant defences and genomic stability, STGaia complements it by replenishing age-depleted squalene and promoting mitochondrial function, skin barrier integrity and cellular energy balance.

“Together, TocoGaia and STGaia provide a clean-label, clinically supported foundation for brands formulating science-backed solutions for longevity, beauty-from-within, and total wellness,” concludes PhytoGaia.

Nutrition Insight recently sat down with Aris to explore key trends and innovations shaping market growth. He highlighted the current aging population is projected to reach 1.6 billion by 2050, noting that cognitive health, memory support, and mental clarity are top priorities.