17 Jul 2018 --- A novel drug based on capsaicin, the compound that gives chili peppers their spicy burn, caused long-term weight loss and improved metabolic health in mice eating a high-fat diet, new studies from the University of Wyoming School of Pharmacy have found. The drug, called Metabocin, was designed to slowly release capsaicin throughout the day so it can exert its anti-obesity effect without producing inflammation or adverse side effects.