Scientists indicate that diet affects cancer therapy efficacy through interactions between phytochemicals in the liver and gut microbiome. In a new study, they suggest that ketogenic or high-carbohydrate diets low in phytochemicals, especially soyasaponins from soybeans, help treat cancer in mice. The study investigates phosphoinositide 3-kinase (PI3K) inhibitors, a class of cancer medications that blocks the PI3K signaling pathway to slow down cancer. This insulin-signaling pathway is among the most frequently activated pathways in human cancer.