18 Feb 2016 --- Reported food hypersensitivity to basic foods such as milk, egg, fish and wheat was eight times higher than allergies confirmed by allergy tests, a Swedish dissertation on young schoolchildren has shown.
Anna Winberg, paediatrician at the Child and Adolescent Clinic at the University Hospital of Umeå, northern Sweden, and author of the PhD study dissertation explains: “Most children with allergies to basic foods will develop tolerance before school age. It is therefore important to recurrently evaluate if the child’s suspected or proven allergy has disappeared.”
“Parents might have been advised to exclude certain foods from the child’s diet due to suspected hypersensitivity in the child during its first year of life. However, this elimination diet often continues until the child reaches 11-12 years of age, without the ‘food allergy’ having been evaluated. Many school children, therefore, remain on an elimination diet although it is no longer necessary, which can lead to a lower intake of important nutrients.”
The study was conducted as a joint project between the OLIN studies (Obstructive Lung Disease in Norrbotten) and Umeå University. In 2006, all school children at the age of 7–8 in the three municipalities Luleå, Kiruna and Piteå were invited to participate in the study, which covered a parental questionnaire with questions on asthma, rhinitis, eczema and food allergies. 2,585 children (96 percent) participated. When the children were 11–12 years of age, a follow-up using the same methods was performed together with a measurement of BMI. The participation was equally high in the follow-up study in 2010. Children with a reported food allergy were invited to clinical trials and blood tests. Children who were categorised as having a current food allergy were then tested further with a double-blind placebo-controlled food challenge (allergy test).
Results showed that ongoing food allergy actually was rare in children who avoided basic foods due to perceived hypersensitivity. The study showed:
• Reported food hypersensitivity at the age of 7–8 was common (21 percent) and in a follow-up study at the age of 11–12, the prevalence had increased to 26 percent.
• Reported allergy to basic foods was eight times higher (5 percent) than the prevalence of allergy confirmed by allergy tests (0.6 percent).
• Despite that 14.5 percent of children at the age of 11–12 years reported that they fully or partly avoided milk due to perceived hypersensitivity, only 3 percent of these children had an ongoing milk allergy.
• Children with ongoing or outgrown milk allergy had a lower body mass index (BMI) compared to children who did not avoid milk.
There is no exact data available on the prevalence of food allergies in Sweden, but an estimated figure of around 5–8 percent of children and 3–5 percent of adults are affected. Younger children with food allergies are often allergic to basic foods, milk in particular. Older children and adults are more often allergic to nuts, fish and shellfish. It has been previously shown that the majority of children allergic to basic foods become tolerant, often before school age.
“The results of this study show how important it is with correct allergy diagnoses and to recurrently evaluate children’s food allergies to avoid unnecessary elimination of food,” says Winberg.
The study also examined biomarkers in blood and stool samples in relation to the outcome of the allergy tests. Some of the analysed biomarkers showed promising results as potential, future prognostic markers of an ongoing food allergy. These results, however, need further validation by future studies.