23 Sep 2015 --- Defective signaling in the brain can cause overeating of high fat foods in mice, leading to obesity, according to one of the first research articles published in the new open access journal Heliyon. The body controls food intake by balancing a need for food to survive with a desire for food for pleasure. By shifting the balance between these systems, defective brain signaling can cause pleasure to take over, resulting in overeating and obesity.