White Wine Could Increase Melanoma Risk

01 Dec 2016 --- Alcohol intake has been associated with higher rates of invasive melanoma among white men and women, according to a new study. White wine carried the most significant association, and the increased risk was greater for parts of the body that receive less sun exposure. The study was published in the journal Cancer Epidemiology, Biomarkers & Prevention.

Previous research has suggested that alcohol can cause carcinogenesis as the ethanol in alcohol metabolizes into acetaldehyde, which damages DNA and prevents DNA repair.

Approximately 3.6 percent of cancer cases worldwide have been attributed to alcohol, most typically cancers of the aerodigestive tract, liver, pancreas, colon, rectum, and breast.

This new study saw researchers seek to determine whether alcohol consumption increased the risk of melanoma, specifically.

They used data from three large prospective cohort studies in which participants were followed for a mean of 18.3 years, using food-frequency questionnaires to determine their alcohol consumption. Non-whites were excluded, as there were too few non-white participants to draw statistically valid conclusions.

The results showed that alcohol intake was associated with a 14 percent higher risk of melanoma per drink per day, while each drink per day of white wine was associated with a 13 percent increased risk of melanoma.

Other forms of alcohol such as beer, red wine, and liquor, did not significantly affect melanoma risk.

Interestingly, the association between alcohol and melanoma was strongest for parts of the body that typically receive less sun exposure.

The researchers said that compared with nondrinkers, those who consumed 20 grams or more of alcohol per day were 2 percent more likely to be diagnosed with melanomas of the head, neck, or extremities, but 73 percent more likely to be diagnosed with melanomas of the trunk.

Eunyoung Cho, ScD, an associate professor of dermatology and epidemiology at the Warren Alpert Medical School of Brown University in Providence, Rhode Island, said this finding was novel and further research would be required to explain the results.

“It was surprising that white wine was the only drink independently associated with increased risk of melanoma.”

“The reason for the association is unknown. However, research has shown that some wine has somewhat higher levels of pre-existing acetaldehyde than beer or spirits. While red and white wine may have similar amounts of pre-existing acetaldehyde, the antioxidants in red wine may offset the risks.”

Cho said the study adds melanoma to the list of cancers associated with alcohol, and the findings support existing recommendations by organizations including the American Cancer Society to limit alcohol intake.

"The clinical and biological significance of these findings remains to be determined, but for motivated individuals with other strong risk factors for melanoma, counselling regarding alcohol use may be an appropriate risk-reduction strategy to reduce risks of melanoma as well as other cancers," Cho said.

However, Cho pointed out that modest alcohol intake has been connected with reduced risk of cardiovascular disease.

"For drinkers, risks and benefits of alcohol consumption have to be considered individually, including the risk related to skin cancer," she said.