Unpredictable stimulant? Higenamine dosage variation forms major threat, warn researchers

07 Sep 2018 --- New peer-reviewed research into weight-loss and sports/energy supplements containing higenamine has found unpredictable, inaccurately labeled and potentially harmful dosages of the stimulant. Based on the findings, the researchers are urging consumers to use caution when consuming supplements labeled as containing higenamine. The use of dietary supplement leads to an estimated 23,000 emergency department visits each year in the US, and weight loss and sports supplements contribute to a large portion of these emergency department visits. The cardiovascular stimulant higenamine was added by the World Anti-Doping Agency (WADA) to the list of substances prohibited in sport two years ago. 

“We’re urging competitive and amateur athletes, as well as general consumers, to think twice before consuming a product that contains higenamine,” says John Travis, Senior Research Scientist at NSF International and a co-author of the study. 

“Beyond the doping risk for athletes, some of these products contain extremely high doses of a stimulant with unknown safety and potential cardiovascular risks when consumed. What we’ve learned from the study is that there is often no way for a consumer to know how much higenamine is actually in the product they are taking,” Travis says.

The study was conducted by researchers at global public health organization NSF International, Harvard Medical School and the National Institute for Public Health and the Environment (RIVM) in the Netherlands. The researchers studied 24 products labeled as containing higenamine or the synonyms “norcoclaurine” or “demethylcoclaurine” and found unpredictable and potentially harmful quantities of the stimulant ranging from trace levels to 62 mg per serving. 

Of the 24 products tested, only five listed a specific quantity of higenamine on the label, and none of those five quantities were accurate. Based on the labeled directions for use, consumers could be exposed to up to 110 mg of higenamine per day. The health risks of higenamine remain poorly understood, but as a beta-2 agonist, it has been prohibited from sport by the WADA, and therefore poses a risk to competitive athletes’ careers.

“Some plants, such as ephedra, contain stimulants. If you take too much of the stimulants found in ephedra, it can have life-threatening consequences. Similarly, higenamine is a stimulant found in plants,” says Dr. Pieter Cohen, Associate Professor of Medicine at Harvard Medical School, Internist at Cambridge Health Alliance and a co-author of the study. “When it comes to higenamine, we don't yet know for certain what effect high dosages will have in the human body, but a series of preliminary studies suggest that it might have profound effects on the heart and other organs."

“Higenamine is a natural constituent of several traditional botanical remedies, such as aconite root and Aristolochia brasiliensis,” said Travis. “While higenamine is considered a legal dietary ingredient when present as a constituent of botanicals, our research identified concerning levels of the stimulant and wildly inaccurate labeling and dosage information. And, as a WADA-prohibited substance, any amount of higenamine in a dietary supplement should be of concern to the competitive athlete.” 

The research, published in the journal Clinical Toxicology, points to the need for independent testing and certification of dietary supplements, a public health service that NSF International provides.

NSF International facilitated the development of the only American National Standard for dietary supplements (NSF/ANSI 173), which became the foundation of NSF’s accredited dietary supplement certification program in 2001 (ANSI-Accredited Product Certification Body – Accreditation #0216). To earn NSF certification, products are tested for product formulation, label claims and harmful levels of specific contaminants and potentially harmful ingredients.