Mitsubishi Gas Chemical boosts cognition and healthy aging through the mitochondria

A growing consumer interest in healthy aging drives demand for nutrition to support brain health and cognition. In this space, Mitsubishi Gas Chemical offers a naturally derived and pure source of pyrroloquinoline quinone disodium salt (PQQ). Branded under MGCPQQ, the ingredient is produced through a proprietary fermentation process.

PQQ is a naturally occurring antioxidant found in trace amounts in vegetables, fruits, eggs, dairy, meat, and fermented foods. The compound is also present in human and animal tissues, with research finding particularly high concentrations in human breast milk. 

Research indicates that MGCPQQ can promote neurogenesis and reduce oxidative stress in the brain. The company says numerous studies have examined PQQ’s benefits in delaying aging by promoting mitochondrial health and improving cognitive function in humans and animals. 

Nutrition Insight meets with Atsushi Sugimoto, assistant manager of Mitsubishi Gas Chemical, to examine how the company’s brain health ingredient supports mitochondrial function and protects against cognitive decline. 

He says there is “no evidence that humans or animals can synthesize PQQ on their own, making it necessary for consumers to seek foods or dietary supplements to maintain adequate levels in the body.” 

“While other forms of PQQ are available on the market, the vast majority of scientific research has been developed using MGCPQQ specifically,” Sugimoto adds. 

According to scientific studies, he says that when taken daily, the ingredient can enhance focus, memory, mood, and cognitive health. “Research has also indicated that MGCPQQ can lower stress, improve sleep, and boost energy — all important markers that can help the brain perform at its best.”

“In recent years, the correlation between the gut and the brain has been attracting attention, so we plan to investigate its effects on gut health. The effect of PQQ on the flora system may be a clue to link the various health benefits that have been revealed so far.” 

Natural fermentation process

As of 2018, the EU authorizes MGCPQQ as a Novel Food. “As a result, MGCPQQ is the only PQQ authorized to be sold in the EU,” says Sugimoto.

In addition to focus, memory, mood, and cognitive health, research indicates that MCPQQ can lower stress, improve sleep, and boost energy.“Some other forms of PQQ available are derived using a synthetic process,” he adds. “Therefore, consumers cannot be assured that the reagents and solvents used in such processes are approved food-safe additives or that they are free from potentially harmful chemicals.” 

“Also, even those produced by fermentation processes must have used microbial strains verified for safety by the European Food Safety Authority.” 

Sugimoto highlights that MGCPQQ has undergone comprehensive testing on safety and efficacy over the past 40 years in over 1,000 in vitro, animal, and human clinical studies. Human trials consistently show “no side effects or adverse biochemical or liver function test results.”

Mitochondrial support

According to these trials, MCCPQQ may promote the development and health of mitochondria and boost the Nerve Growth Factor, explains Sugimoto. This factor is important for neuron development and provides antioxidant protection to brain cells. 

“As the powerhouse of cells, mitochondria are responsible for regulating cognitive function, memory, energy, and mood.” 

“While a healthy body continually creates mitochondria in a process known as mitochondrial biogenesis, mitochondrial function begins to decline as one ages, which can lead to impaired functioning of the brain and other vital organs. Health issues, such as sarcopenia, infections, diabetes, dementia, and other neurodegenerative diseases, can become present when mitochondria are damaged.” 

He says that MGCPQQ can support consumers in maintaining healthy mitochondria, “refueling the body so that one can live healthier as they age.”

Mitochondria in cells are responsible for regulating cognitive function, memory, energy, and mood, explains Sugimoto.Nutrition companies increasingly explore healthy aging solutions as people typically spend the last ten years of their lives in poorer health. However, IFF Health Sciences told us there is untapped potential in the market, noting a lag in product launches for healthy aging.

Boosting brain and mental health

Sugimoto points to several scientific studies underpinning the benefits of MGCPQQ in enhancing focus, memory, mood, and cognitive health when taken daily. 

“MGCPQQ improves selective attention and working ability after 12 weeks of taking 20 mg, according to a study of 41 healthy elderly subjects,” he details. 

“MGCPQQ boosts short-term memory after six months of taking 20 mg daily, according to a study of 65 middle-aged to elderly subjects. MGCPQQ also improves composite and verbal memory after 12 weeks when taking the same dosage, another study of older adults (41–65) found.”

In improving mood, Sugimoto says the compound reduces confusion, anxiety, and depression and enhances vigor after taking 20 mg a day for eight weeks, according to a study of 17 adults.

Moreover, in a study of 71 healthy adults aged 45–65, the compound increased memory recall, reversed the decline in cognitive function, and improved overall higher brain functions such as spatial awareness after taking 20 mg a day for 24 weeks. 

“It also improves cognitive flexibility, processing speed, and execution speed after taking 20 mg a day for eight weeks, according to a study of younger adults (20-40),” he adds.  

Sugimoto says that foods rich in vitamins, minerals, and antioxidants can help fuel the brain, along with physical activity and rest.Last year, an in vitro study also indicated that PQQ may help protect cells against coronaviruses. 

Nutrition and lifestyles

Meanwhile, Sugimoto highlights the benefits of diet and lifestyle choices to support long-term brain health. 

“High-quality foods rich in vitamins, minerals, and antioxidants can essentially help to fuel the brain, providing nutrients vital for development, cognitive function, and protection. Fruits and vegetables have shown they can protect the brain from oxidative stress, which can damage brain cells. Numerous studies indicate berries and nuts, which are an excellent source of protein, can also help improve memory.”

In addition, he says regular physical activity can aid with learning, problem solving, and thinking better, while contributing to improved memory. “Staying active helps deliver more oxygen to the brain and bloodstream, making one feel more alert and awake. Studies have also shown exercise can help minimize the risk of cognitive decline, including dementia.”

Sugimoto stresses the importance of proper rest for overall recovery. “Getting quality sleep regularly is also crucial for cognitive health and brain development. Research has shown that a good night’s rest can help the brain restore and repair itself so one functions at their best, thinks more clearly, and improves memory.” 

“Studies have also demonstrated sleep supports better focus, enhanced problem-solving skills, and greater creativity,” he adds.