13 Jan 2016 --- In a newly published systematic review the proof of effect on infant colic was further strengthened for L. reuteri Protectis. The review evaluated 17 studies of different treatments of infant colic, whereof L. reuteri Protectis was the only probiotic. Only one other product was deemed effective. Simethicone, a drug often prescribed for colic, was shown to have no effect.