HOTSHOT: A New Solution to Boost Neuro Muscular Performance

03 Jun 2016 --- New research has led to the development of a revolutionary new sports shot, HOTSHOT, that is scientifically proven to prevent and treat muscle cramps by stopping them where they start: at the nerve. Millions of athletes and fitness enthusiasts suffer from exercise-associated muscle cramps – even the best trained and most nutritionally-savvy. 

Existing "remedies" that target the muscle have limited scientific evidence that they work. However, now a scientific breakthrough in sports nutrition has been made to change the game for these athletes. 

The findings were presented at the American College of Sports Medicine's Annual Meeting, and will be published in the Journal of the American Medical Athletic Association later this month.

HOTSHOT, previously codenamed #ITSTHENERVE, is a 1.7 fluid ounce sports shot comprised of a proprietary formula of GMO-free organic ingredients with a kick. 

Consumed before, during or after exercise, HOTSHOT facilitates the synchronization of communication between the nerve and muscle thereby giving athletes greater control over the way their nerves and muscles work together, boosting their Neuro Muscular Performance (NMP) to prevent and treat muscle cramps. Now athletes can push harder, train longer and finish stronger.

Rod MacKinnon, MD, a Nobel Prize-winning neuroscientist, along with close friend and colleague Bruce Bean, PhD, a neurobiology professor at Harvard Medical School, sought to find a cure for cramping after a life-threatening event occurred off the coast of Cape Cod in 2010. The pair was enjoying a long-distance sea kayaking trip when almost simultaneously their arms seized up miles from shore, in dangerous conditions. Both were surprised by the muscle cramps because they had taken precautions to stay well-hydrated and topped up on electrolytes.

Curious as to what was known about the cause and cure of muscle cramps, MacKinnon and Bean consulted literature and realized that cramping is not caused by dehydration or electrolyte imbalance, but instead originates from hyper-excited motor-nerves in the spinal cord.

Building off MacKinnon's Nobel Prize-winning research on ion channels, they hypothesized that activating certain Transient Receptor Potential (TRP) ion channels in sensory nerves in the mouth, throat and esophagus could send signals to calm those hyper-excited motor neurons, thereby stopping muscle cramps before they start.

Over several years, they experimented with numerous natural ingredients that activate certain TRP ion channels and refined the proprietary formula of ingredients found in HOTSHOT – now scientifically proven to prevent and treat muscle cramps.

In their pursuit to find a solution for muscle cramps, MacKinnon and Bean accidentally unlocked the power of NMP – the way that an athlete's nerves and muscles work together in an optimal way. New evidence shows that boosting NMP also reduces post-exercise muscle soreness. The exercise-associated muscle cramp study of HOTSHOT conducted by Penn State University showed a statistically significant reduction in muscle soreness during the first 20 minutes after a muscle cramp, compared to placebo. And in field studies among athletes using HOTSHOT prior to working out, the majority reported reduced post-exercise soreness.

"I am not aware of any other consumer product that has demonstrated significant efficacy in mitigating muscle cramps in such a rigorous double-blind scientific study," said Larry Kenney, Ph.D., FACSM, Marie Underhill Noll Chair in Human Performance and Professor of Physiology and Kinesiology at Penn State University.

"This is a brand new concept in sports nutrition: how to stimulate sensory nerves as a way to affect your muscle function," said MacKinnon. "This is cool science. The breakthrough and what we now know is how to prevent and treat muscle cramps. However, what intrigues me is what I'm hearing from athletes about other potential benefits. This is only the beginning."

The company's scientists, in partnership with leading sports science institutions, are continuing to study how HOTSHOT affects boosting an athlete's NMP and how that may translate to additional benefits for athletes.

The proprietary HOTSHOT formulation is NSF Certified for Sport, and has been extensively tested by amateur and world-class athletes across endurance sports, track and field, professional football and tennis. 

"I have been an endurance athlete for over 20 years," said Craig 'Crowie' Alexander, 5-time IRONMAN and IRONMAN 70.3 World Champion. "Muscle cramps are a source of concern for me because they put a brake on your momentum. They can strike at the beginning of the race or when you are meters from the finish line. A cramp can paralyze you mentally, and physically, and cost you crucial time. So HOTSHOT is a big confidence-builder and game changer in endurance sports, knowing you won't be stopped in your tracks by cramping."

HOTSHOT is a product of Flex Innovation Group LLC, a division of Flex Pharma, Inc.