Why Obesity Leads to More Aggressive Prostate Cancer

635882818915684243waistline.jpg

14 Jan 2016 --- Obesity has direct consequences on health and is associated with the onset of aggressive cancers, but the mechanisms underlying this phenomenon are little known. Researchers from the Institut de Pharmacologie et Biologie Structurale (CNRS/Université Toulouse III - Paul Sabatier) have recently elucidated one of these mechanisms in prostate cancer, one of the most common cancers in men: in obese patients, the adipose tissue surrounding the prostate gland facilitates the spread of tumor cells outside the prostate. A patent has been filed for these results, which open new avenues for the treatment of prostate cancer, and are published in Nature Communications on January 12, 2016.

The prostate is surrounded by a fatty deposit called periprostatic adipose tissue (PPAT). As prostate cancer progresses, tumor cells may infiltrate this periprostatic adipose tissue: this is a key step in the progression of this cancer, as it signals locally advanced disease (where the cancer can progress to nearby organs). This phenomenon is more frequent in obese patients, in whom the size and number of PPAT adipocyte cells are higher. These cells can secrete numerous bioactive molecules such as chemokines, which can attract other cells. The scientists investigated whether this change in PPAT was responsible for the aggressiveness of prostate cancer in obese subjects.

The researchers showed that adipocyte secretions can attract prostate tumor cells. By analyzing chemokines secreted by PPAT adipocytes they identified the factors involved, in particular chemokine CCL7, which interacts with one of its receptors, CCR3, present on the surface of prostate tumor cells. The scientists demonstrated that chemokine CCL7 is diffused through the PPAT to the area around the prostate and that it attracts tumor cells that express the CCR3 receptor towards the periprostatic adipose tissue, the gateway to the rest of the body.

The researchers then tested the influence of obesity on this mechanism. They showed that in obese mice who had been fed a high-fat diet, tumor progression and dissemination outside the prostate is greater than in mice with normal body weight. Adipocytes do indeed secrete more CCL7 in the case of obesity. When tumor cells that no longer express CCR3 are implanted in the prostates of mice, tumor progression and dissemination are significantly reduced, especially in obese mice.

Finally, the researchers observed this same mechanism in men where CCL7 secretion is also higher in case of obesity. The results of a study of more than 100 human tumor samples show that the tumors expressing a high level of CCR3 present more frequent local dissemination. They are also more aggressive and resistant to treatment. Since molecules that target CCR3 have already been developed by the pharmaceutical industry for other diseases, the researchers are now hoping to explore this new therapeutic pathway, which could reduce the aggressiveness of prostate cancer in obese patients.
 

Related Articles

Nutrition & Health News

Drink your vitamins: SternVitamin launches micronutrient premix for beverages 

19 Feb 2018 --- A healthy lifestyle is essential to all age groups, and nutrition plays a major role alongside various other components. SternVitamin is now offering beverage manufacturers a novel way to address the topic of health with a new micronutrient premix for healthy bones and heart. SternVitamin notes that the mix picks up on one of the top trends in the beverage market – water-based enriched products. The vegan premix contains vitamins B1, B12, C, K2 and D3. Organic agave syrup powder gives it a slight sweetness, while natural flavors give the drink a “dark berry” taste. It dissolves clear in water and leaves no turbidity. 

Nutrition & Health News

Yogurt may reduce cardiovascular disease risk

19 Feb 2018 --- A higher yogurt intake is associated with lower cardiovascular disease risk among hypertensive men and women, a study in the American Journal of Hypertension suggests. High blood pressure is a major cardiovascular disease risk factor. Clinical trials have previously demonstrated beneficial effects of dairy consumption on cardiovascular health, and yogurt may independently be related to cardiovascular disease risk.

Nutrition & Health News

“Unhelpful”: EU regulatory framework fuels nutrition industry dissatisfaction 

16 Feb 2018 --- A survey reveals that one-third of all nutrition industry professionals believe that the current EU framework for achieving a health claim on new products is stunting innovation because it’s complicated, expensive, long-winded and has several “gray areas.” And “regulation frustration” is a strong feeling running through the industry with many more professionals now believing the current EU regulatory environment is “unhelpful” – a 25 percent hike compared with statistics from the beginning of 2017. Experts are attributing this sharp rise in dissatisfaction to the EU’s tough stance on health claims and the current regulatory deadlock on botanicals.

Nutrition & Health News

Indulgence has reached even America’s healthiest eaters: research

16 Feb 2018 --- New research reveals even the US’ healthiest eaters reach for indulgence foods based on their emotional states. Forty percent of US food-brand lovers who rated their daily diet as extremely healthy agreed with the statement, “When I’m feeling down, I eat something indulgent to make me feel better.” The study, conducted by full-service food branding agency, Foodmix Marketing Communications, breaks out a large group of brand lovers into smaller, differentiated and more actionable consumer segments.  

Nutrition & Health News

Research driving demand for OPO in China’s formula market: Advanced Lipids

16 Feb 2018 --- OPO is increasing in popularity in China’s infant formula market, and according to Advanced Lipids, this is down to the growing body of scientific research backing the benefits of this ingredient. Also known as SN-2 palmitate, OPO is a premium quality ingredient that mimics the fatty acid profile of human milk.

More Articles
URL : http://www.nutritioninsight.com:80/news/why-obesity-leads-to-more-aggressive-prostate-cancer.html