Scientists find natural mimetics of anti-cancer and anti-aging drugs

ea1e96d9-f897-440f-bd93-5244b29f1610articleimage.jpg

04 Dec 2017 --- Researchers from the Biogerontology Research Foundation in the UK, Insilico Medicine, Life Extension and other institutions have announced the publication of a landmark study in the journal Aging on the identification of natural mimetics of metformin and rapamycin.

Metformin, a common Type 2 diabetes drug, and rapamycin, a common anti-rejection drug, have both been shown to have substantial anti-aging and anti-cancer effects in a variety of model organisms. However, both compounds have known side effects and are regulated drugs for existing disease indications, factors that problematize their off-label use as healthspan-extending drugs.

Natural compounds mimic crucial drugs
In the Aging study, the researchers applied deep-learned neural networks to profile the safety and gene- and pathway-level similarity of more than 800 natural compounds to metformin and rapamycin, in an effort to identify natural compounds that can mimic the effects of these anti-cancer and anti-aging drugs while remaining free of the adverse effects associated with them.

“Earlier this year we launched Young.AI, a comprehensive system utilizing the recent advances in deep learning for tracking a variety of aging biomarkers,” says Alex Zhavoronkov, Ph.D., co-author of the study, founder of Insilico Medicine and Chief Science Officer of the Biogerontology Research Foundation. “I hope that the consumers using the Longevity AI will start using it. One of the goals of our group is to identify the combinations of molecules that achieve the desired effects.”

The researchers’ analysis identified many novel candidate metformin and rapamycin mimetics that have been previously unreported as such. In particular, they identified allantoin and ginsenoside as strong mimetics of metformin, epigallocatechin gallate and isoliquiritigenin as strong mimetics of rapamycin, and withaferin A as a strong mimetic of both. Additionally, their analysis also identified four previously unexplored natural compounds as fairly strong mimetics of rapamycin.

“Aging is not recognized as a disease, so we need strong potential geroprotectors of natural origin on the market. Supplements that slow down aging, affecting the key mechanisms of aging at the molecular and cellular level,” says Alexey Moskalev, Ph.D., a co-author of the study.

These findings are significant because, as naturally occurring compounds, such nutraceuticals are not subject to regulation by the FDA and other regulatory bodies. Furthermore, because the researchers induced a deep-learning based classification of the safety profiles associated with these compounds, the novel candidate mimetics the study identified are likely to have less adverse effects than metformin and rapamycin, though this needs to be further validated by clinical testing.

“This study is significant not only for the identification of novel candidate mimetics of metformin and rapamycin – which as natural compounds are not subject to regulatory bodies like the FDA and which have higher-scoring safety profiles as indicated by our deep-learned safety profile classification analysis – but also for demonstrating particularly powerful screening methods that can be applied to the identification of novel and safe mimetics of other known anti-cancer and healthspan-extending drugs and compounds,” says Franco Cortese, co-author of the study and Deputy Director of the Biogerontology Research Foundation.

The paper can be accessed here.

To contact our editorial team please email us at editorial@cnsmedia.com

Related Articles

Nutrition & Health News

Weekly Digest: Arla expands fiber yogurt range, probiotics may reduce hay fever symptoms

25 May 2018 --- This week in nutrition news, Arla revealed a new addition to its fiber yogurt range, hoping to boost the UK's daily fiber intake. In research news, probiotic formulations were found to have positive effects on hay fever symptoms, while following a diet high in antioxidants may protect people from the adverse effects of pollution. Furthermore, researchers have made steps in understanding the link between a mothers nutrition during pregnancy and the child's growth, and a study undercovered that consumers are more likely to order unhealthy options when dining out amid louder, ambient music.

Nutrition & Health News

calocurb: 100 percent plant-based weight management product launched in US market

25 May 2018 --- New Zealand-based nutrition and e-commerce company calocurb has launched its 100 percent plant-based, non-GMO weight management supplement into the US market. The product is designed to curb cravings and reduce calorie intake by around 20 percent at meal or snack time.

Nutrition & Health News

Microbiome solutions: A key theme at Vitafoods Europe 2018

24 May 2018 --- Research into the microbiome – the aggregated microbial species in our body – is gaining increasing attention and investment. Although the term is often associated with digestive health, the body, in fact, contains multiple microbiome. This is currently spurring on research and innovation in areas as wide-ranging as women’s health, weight management, immunity and skin health. At Vitafoods Europe 2018, NutritionInsight spoke with suppliers about their efforts and innovations in the microbiome space, using pre or probiotics for gut health and beyond.

Nutrition & Health News

Athletic endurance improved with Beneo's low glycemic carb, study finds

24 May 2018 --- Athletes who consumed a drink containing the functional carbohydrate, Palatinose, before exercise exhibited improved cycling performance, a study at the University of Freiburg has found. This was in comparison with participants who were given maltodextrin, a high glycemic carbohydrate, before exercising. The study's findings could hold potential for the use of Palatinose as a sports nutrition ingredient.

Nutrition & Health News

UK sugar reduction efforts fail to reach initial target, industry urged to step up or face tax

23 May 2018 --- The first assessment of the UK government’s sugar reduction program has unveiled failings by industry to reduce sugar in the first year by 5 percent, leading to calls of a sugar tax on sweet treats. The results of the first year have been roundly criticized in the media and described as “hugely disappointing” after Public Health England data revealed that sugar was cut in some categories – sweet spreads and sauces, yogurts and fromage frais and breakfast cereals – while other food groups have fallen short.

More Articles
URL : http://www.nutritioninsight.com:80/news/scientists-find-natural-mimetics-of-anti-cancer-and-anti-aging-drugs.html