Resveratrol Could Suppress Pathogen that Causes Inflammation

636125556337570698^A49F39700069E1FC93AF81B064B13A4296651593A7481E89AF^pimgpsh_fullsize_distr.jpg

20 Oct 2016 --- Resveratrol, a component of red wine and grapes, may help control inflammation induced by a bacterial pathogen that is linked to upper respiratory tract inflammatory diseases, according to a new study published in Scientific Reports.

“It has been shown that resveratrol can suppress inflammation, but how it regulates inflammation still remains largely unknown,” said Jian-Dong Li, a senior author of the study, director of the Institute for Biomedical Sciences at Georgia State, and a Georgia Research Alliance Eminent Scholar.

“We found that resveratrol suppresses a major bacterial pathogen causing otitis media and chronic obstructive pulmonary diseases (COPD) by up-regulating or increasing the production of a negative regulator called MyD88 short.”

Resveratrol belongs to a group of compounds called polyphenols that are thought to act like antioxidants and protect the body against damage. It has long been considered a therapeutic agent for various diseases, including inflammatory diseases.

In the study, resveratrol was effective against inflammation caused by nontypeable Haemophilus influenzae (NTHi), a major respiratory pathogen.

This study found for the first time that resveratrol decreases NTHi-induced expression of pro-inflammatory mediators in airway epithelial cells and in the lungs of mice by enhancing MyD88 short, a negative regulator of inflammatory signaling pathways.

MyD88 short is considered a “brake pedal protein” because it can tightly control inflammation induced by this respiratory pathogen. It could be a critical target with significant therapeutic potential for suppressing inflammation associated with chronic airway disease.

The researchers also found that resveratrol has anti-inflammatory effects after NTHi infection, which demonstrates its therapeutic potential.

Related Articles

Nutrition & Health News

BASF targets fatty liver disease with US launch of Hepaxa product

23 Feb 2018 --- BASF is launching Hepaxa to help patients manage non-alcoholic fatty liver disease in what the corporation describes as “the first dedicated product in the US” to potentially assist tens of millions of patients with one of the most common forms of chronic liver disease. And it could begin to “turn around” non-alcoholic fatty liver disease (NAFLD) in as little as six months, according to BASF executives. 

Nutrition & Health News

Plant power: Optimum Nutrition launches brand's first plant-based protein

23 Feb 2018 --- Performance nutrition supplier Optimum Nutrition ("ON") is expanding its Gold Standard protein line with the brand's first plant-based protein powder. Fitting nicely within the trend toward plant-based offerings to suit athletes of all levels, ON Gold Standard 100% Plant has a multisource blend of premium, plant-based protein that delivers a complete profile of essential amino acids, outstanding taste and texture, without any artificial flavors, colors or sweeteners.

Nutrition & Health News

Collagen peptides: Innovation platforms far from exhausted, says Rousselot exec

22 Feb 2018 --- Boosted by a growing body of scientific research, collagen peptides have risen in popularity over the past years. In fact, Innova Market Insights figures show that there was a +34 percent compound annual growth rate (CAGR) in new product launches for collagen peptides from 2010 to 2016. However, there is still ample room for further growth and research, according to Lisette van Lith, Global Director of Rousselot's Peptan, who spoke with NutritionInsight about her new role and regional inspiration for the usage of collagen peptides. 

Nutrition & Health News

Naturex targets oral care market with microbiota-balancing natural active

22 Feb 2018 --- Naturex has launched Bucovia, a natural bio-guided fractionated active aimed at effectively supporting mouth health. Current oral healthcare solutions include biocides (antiseptic or antibiotic), synthetic ingredients that wipe out both good and bad mouth bacteria and increase the virulence of Candida. Naturex’s new solution is composed of active compounds from Solidago virgaurea, a European plant containing saponins that are effective in controlling the growth of mixed fungal-bacterial biofilms. Bucovia regulates Candida albicans genes involved in biofilm formation and inhibits its bacterial partners. 

Nutrition & Health News

“Beetroot pill” could help reduce the risk of kidney failure after heart x-ray

22 Feb 2018 --- The humble beetroot may be the key to reducing the risk of kidney failure in patients having a heart x-ray. This is according to research led by Queen Mary University of London, which has embarked on a new research project funded by national charity Heart Research UK will look into whether dietary inorganic nitrate found commonly in beetroot could be used in pill form to prevent one of the most common causes of kidney failure in hospital.

More Articles
URL : http://www.nutritioninsight.com:80/news/resveratrol-could-suppress-pathogen-that-causes-inflammation.html