Indena Boswellia formulation shown to alleviate IBS symptoms

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17 Jul 2017 --- A new study has shown that Casperome, the Indena Phytosome formulation of Boswellia serrate that delivers the full natural bouquet of triterpenoids, offers rapid relief to sufferers of irritable bowel syndrome (IBS). Affecting 10 to 20 percent of the adult population and often unrecognized or untreated, Irritable bowel syndrome (IBS) is a chronic, relapsing gastrointestinal disorder. 

The supplement registry study, published in the European Review for Medical and Pharmacological Sciences, enrolled 71 otherwise healthy subjects with idiopathic IBS that each decided to follow a different management strategy. Group one took Hyoscine butylbromide, administered when needed. Group two took 10mg of papaverine hydrochloride and 10mg of belladonna extract, administered when needed. Group three used a supplementation with Casperome, one tablet of 250mg per day, for four weeks. All groups were comparable in term of age and gender distribution and they presented similar clinical characteristics at inclusion. Abdominal pain, altered bowel movements, meteorism and cramps were evaluated by subjects before the inclusion and during the last week before the end of the observational period of four weeks.

All IBS symptoms investigated improved during the period with the three management strategies, but only in the Casperome-supplemented group did the number of subjects with any IBS symptoms significantly decrease, from 58 percent to 12.5 percent. In the Casperome-supplemented group, the number of subjects who needed medical attention significantly decreased to 4.1 percent. In addition, the prevalence of side effects was significantly higher in the two groups treated with the Standard Management Strategies (28 percent for group one and 26 percent for group two) compared to Casperome supplemented subjects (8.2 percent). 

This study demonstrates that Indena’s Casperome supplementation may represent a promising alternative approach to managing symptoms associated with IBS in otherwise healthy subjects.

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Indena S.p.A.

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Indena is the world's leading company in the identification, development and production of active principles derived from plants, for use in the pharmaceutical, health-food and personal care industries.

Indena, a privately owned Italian company, has around 800 employees (10% of them dedicated to full-time research)  and has cultivation, manufacturing, and sales in more than 70 countries throughout the world.

The key to Indena's success is its research, covering: the screening of medicinal plants for pharmacological benefits; the identification of new active principles; the development of cutting-edge extraction and purification systems for industrial applications.

Phyto-chemical research is carried out in Indena's own Research Center in Settala, Italy. Indena also co-operates with the world's most prestige universities and private research institutes in the biological assessment of the safety and effectiveness of its products up to clinical phase I/II.

A key strategic research objective is the development of new active principles for pharmaceutical applications. This also forms an indispensable base for the health-food and personal care industries.

The pharmaceutical side of the company is focused mainly on anti-cancer drugs, which are produced to US-FDA, ICH and EU standards at Indena's High Containment Manufacturing facilities in Settala, Italy. Indena's drug discovery strategy is to develop new chemical entities up to "Phase I/II" of clinical studies, and then license them to pharmaceutical companies.

Today Indena is also concentrating its efforts on the industrial production of high-quality standardised botanical derivatives, which are important ingredients in health food products. In fact, the company produces standardised extracts from edible plants that are traditionally recognised as having therapeutic properties, as well as from plants that have proven pharmacological value. Indena's research and production activities are particularly attentive to plant-based principles that have anti-oxidant properties and prevent damage caused by free radicals.

Backed by more than 90 years of botanical experience, Indena has developed a plantation network, managed by experts, to supply its research and production centres with officinal plants, while ensuring bio-diversity and protecting the ecosystem from uncontrolled harvesting. Today more than 60% of the raw material used in manufacturing comes from cultivations.

Indena's decades-long global presence in the plant extraction industry is a guarantee of its in-depth knowledge and understanding of the business, market trends and legal considerations. There is constant communication and interaction between the company's experts, who cooperate on the updating of all the main pharmacopoeias, and the major international regulatory authorities such as WHO, EMA, and ESCOP.
The company has more than 150 primary patents and has published more than 700 scientific studies.

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