Concerns about antibiotic use and resistance, as full antibiotic course advice challenged

310bd377-ab9b-4b95-b356-9ca42306859earticleimage.jpg

28 Jul 2017 --- The European Food Safety Authority, the European Medicines Agency and the European Centre for Disease Prevention and Control are concerned about the impact of use of antibiotics on the increase in antibiotic-resistant bacteria. A new report presents new data on antibiotic consumption and antibiotic resistance and reflects improved surveillance across Europe.

Vytenis Andriukaitis, European Commissioner for Health and Food Safety says: "To contain antibiotic resistance we need to fight on three fronts at the same time: human, animal and the environment. This is exactly what we are trying to achieve in the EU and globally with our recently launched EU Action Plan on antimicrobial resistance. This new report confirms the link between antibiotic consumption and antibiotic resistance in both humans and food-producing animals."

Experts highlight that there are still important differences across the EU in the use of antibiotics in animals and humans. Cutting their unnecessary use will have an impact on the occurrence of resistance.

Overall antibiotic use is higher in food-producing animals than in humans, but the situation varies across countries and classes of antibiotics. In particular, a class of antibiotics called polymyxins (which includes colistin) is used widely in the veterinary sector. It is also increasingly used in hospitals to treat multidrug-resistant infections. Other antibiotics are more often used in humans than in animals. These include third- and fourth-generation cephalosporins and quinolones, antibiotics that are also considered critically important for human health.

Experts note that resistance to quinolones, used to treat salmonellosis and campylobacteriosis in humans, is associated with use of these antibiotics in animals. The use of third- and fourth-generation cephalosporins for the treatment of infections caused by E. coli and other bacteria in humans is associated with resistance to these antibiotics in E. coli found in humans.

The report is the result of close cooperation between the three EU agencies, each drawing on their specific expertise and data from monitoring of antibiotic resistance and antibiotic consumption in animals and humans.

The conclusions are in line with those of the first report published by the three agencies in 2015. However, the availability of better quality data allowed a more sophisticated analysis.

Experts of the three agencies recommend further research to understand better how use of antibiotics and resistance affect one another.

The news comes as a high profile piece was published in the British Medical Journal (BMJ) on Wednesday, where a group of practicing physicians argues that the idea that stopping antibiotics early may be dangerous to the patient and society as a whole is not grounded in strong science and that policymakers, educators and doctors should drop this message.

In an opinion piece in the BMJ Martin J Llewelyn, professor of infectious diseases. “The idea that stopping antibiotic treatment early encourages antibiotic resistance is not supported by evidence, while taking antibiotics for longer than necessary increases the risk of resistance. Without explicitly contradicting previous advice, current public information materials from the US Centers for Disease Control and Prevention (CDC) and Public Health England have replaced ‘complete the course’ with messages advocating taking antibiotics ‘exactly as prescribed.’ We explore the evidence for antibiotic duration, clinical effectiveness, and resistance, and encourage policy makers, educators, and doctors to stop advocating ‘complete the course’ when communicating with the public. Further, they should publicly and actively state that this was not evidence-based and is incorrect.”

The authors argue: “The concept of an antibiotic course ignores the fact that patients may respond differently to the same antibiotic, depending on diverse patient and disease factors. Currently, we largely ignore this fact and instead make indication specific recommendations for antibiotic duration that are based on poor evidence. This situation is changing in hospital practice, where biomarkers of treatment response such as procalcitonin can guide when to stop antibiotic treatment. Outside hospital, where repeated testing may not be feasible, patients might be best advised to stop treatment when they feel better, in direct contradiction of WHO advice. Of note, a recent clinical trial found that using fever resolution to guide stopping antibiotics in community acquired pneumonia halved the average duration of antibiotic treatment without affecting clinical success. Further similar studies are needed.”

Click to EnlargeImmune health continues to dominate supplement NPD activity. An Innova Market Insights analysis of claims being made on European supplements between 2012 and 2016, finds significant growth for a number of platforms, with a particularly strong rise in products featuring immune health claims, which now accounts over 30% of new launches.

The immune health platform was the leading platform for new supplement launches, accounting for 31% of new supplements reported in 2016. The number of launches continues to grow, by +24% from 2015 to 2016. In Food & Beverages a growing number of launches for this health platform is growing, but it remains a niche in total food innovation.

Related Articles

Nutrition & Health News

Relief from food allergies may come from antibody drug and food desensitization

12 Dec 2017 --- A clinical trial of 48 children with multiple food allergies which tested antibody drug omalizumab alongside food desensitization treatment resulted in more effective allergy relief compared to placebo, according to a study published in The Lancet Gastroenterology & Hepatology journal.

Nutrition & Health News

Energetic growth: Energy boosters add pep to the nutritional space’s step

11 Dec 2017 --- Busy schedules can cause consumers to go through an “energy crisis” – prompting their desire to reach for products that might offer some support to their energy levels. Energy boosters are certainly showing signs of growth in all regions tracked by Innova Market Insights. A CAGR in supplement launches of +208.8 percent in South America from 2012 to 2016 is particularly noteworthy, while Europe is top of the pile worldwide with 28.8 percent of its supplement launches having an energy claim in 2016 and its CAGR amounting to a strong +86.7 percent.

Nutrition & Health News

Kyowa brings Setria Glutathione’s benefits to curious European consumers

05 Dec 2017 --- Following the launch of its flagship Setria Glutathione product, Kyowa Hakko is keenly watching and helping build the European market for immunity, beauty and sports nutrition products at a key time in its development. Earlier this year, the company launched its glutathione product in the European market. Manufactured through a patented fermentation process, the product can help replenish the body’s reserves of glutathione that may be depleted through poor diet, damaging lifestyle habits or aging.

Business News

Novel seaweed extracts: Cancer-inhibiting properties discovered in fucoidans

05 Dec 2017 --- Breakthrough research has confirmed that two unique compounds extracted from a specific seaweed have significant cancer-inhibiting properties. A series of animal studies undertaken at McGovern Medical School, University of Texas Health Science Center in Houston (UTHealth) have shown that the two fucoidans reduced tumor growth in select cancers and significantly improved the effectiveness of the common chemotherapy drug tamoxifen.

Nutrition & Health News

DuPont’s Microbiome Venture aims to lead development of new microbiome science-based solutions

30 Nov 2017 --- DuPont Nutrition & Health has announced the development of what it describes as a “significant new initiative” with the creation of its Microbiome Venture to spearhead the development of new microbiome science-based solutions. The Microbiome Venture will play a key role in DuPont’s business growth strategy.

More Articles
URL : http://www.nutritioninsight.com:80/news/concerns-about-antibiotic-use-and-resistance-as-full-antibiotic-course-advice-challenged.html